margarate (17:0) to decadienedioic acid (c10:2-dc)**

Numerator Metabolite

Structure of margarate (17:0)
Metabolite Accession: GCST90200459
Name: margarate (17:0)
Hmdb Id: HMDB0002259
Super Pathway: NA
Sub Pathway: NA
Inchikey: KEMQGTRYUADPNZ

Denominator Metabolite

Structure of decadienedioic acid (c10:2-dc)**
Metabolite Accession: GCST90200700
Name: decadienedioic acid (c10:2-dc)**
Hmdb Id: HMDB0242172
Super Pathway: NA
Sub Pathway: NA
Inchikey: FRWVXIATCBRYHA

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.267
Position:
102075479
SE (Ratio):
0.024
Effect Allele:
A
Z-score (Ratio):
11.195
Reference Allele:
G
-log10(P):
-65.310
MAF:
0.176
Beta (Num):
0.076
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-0.191
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism

Denominator Metabolite Explanation:

Fatty acid omega-oxidation

Ratio Explanation:

This ratio contrasts an odd-chain saturated fatty acid (margarate) with a dicarboxylic acid, reflecting a balance between fatty acid availability and alternative catabolism.4[1], 5[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SCD activity, a key enzyme in lipid synthesis, likely drives changes in fatty acid pools, reflected by this ratio.1[1], 3[2] This dysregulation is associated with dyslipidemia, atherosclerosis, and increased risk for coronary artery disease and myocardial infarction.1[3], 6[4], 7[5]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data