n-acetylphenylalanine to decadienedioic acid (c10:2-dc)**

Numerator Metabolite

Structure of n-acetylphenylalanine
Metabolite Accession: GCST90200677
Name: n-acetylphenylalanine
Hmdb Id: HMDB0000512
Super Pathway: NA
Sub Pathway: NA
Inchikey: CBQJSKKFNMDLON

Denominator Metabolite

Structure of decadienedioic acid (c10:2-dc)**
Metabolite Accession: GCST90200700
Name: decadienedioic acid (c10:2-dc)**
Hmdb Id: HMDB0242172
Super Pathway: NA
Sub Pathway: NA
Inchikey: FRWVXIATCBRYHA

Associated Genomic Regions

Region: rs2328895

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.311
Position:
25802083
SE (Ratio):
0.021
Effect Allele:
C
Z-score (Ratio):
-15.001
Reference Allele:
T
-log10(P):
-115.460
MAF:
0.444
Beta (Num):
-0.148
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.164
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A4 SLC17A3 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Phenylalanine metabolism, protein degradation.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation.7[1]

Ratio Explanation:

The ratio may reflect altered transport activity by SLC17A4, potentially influencing the clearance of N-acetylphenylalanine, a uremic toxin, and decadienedioic acid.1[1], 8[2], 6[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The SLC17A4 missense variant likely alters urate transport, directly affecting uric acid levels. This alteration in transporter function could also influence the handling of other organic anions, including N-acetylphenylalanine and decadienedioic acid, which may contribute to the observed hematological phenotypes.1[1], 9[2]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data