decadienedioic acid (c10:2-dc)** to xanthurenate

Numerator Metabolite

Structure of decadienedioic acid (c10:2-dc)**
Metabolite Accession: GCST90200700
Name: decadienedioic acid (c10:2-dc)**
Hmdb Id: HMDB0242172
Super Pathway: NA
Sub Pathway: NA
Inchikey: FRWVXIATCBRYHA

Denominator Metabolite

Structure of xanthurenate
Metabolite Accession: GCST90199626
Name: xanthurenate
Hmdb Id: HMDB0000881
Super Pathway: NA
Sub Pathway: NA
Inchikey: FBZONXHGGPHHIY

Associated Genomic Regions

Region: rs2762353

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.271
Position:
25794431
SE (Ratio):
0.022
Effect Allele:
A
Z-score (Ratio):
12.494
Reference Allele:
G
-log10(P):
-80.809
MAF:
0.445
Beta (Num):
0.163
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.108
SE (Den):
0.016
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A4 SLC17A3 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

omega-oxidation, fatty acid oxidation8[1]

Denominator Metabolite Explanation:

Tryptophan metabolism9[1], 10[2], 11[3]

Ratio Explanation:

An elevated ratio of decadienedioic acid to xanthurenate could indicate a shift in metabolic flux, possibly due to altered transporter activity by SLC17A4, though direct evidence is lacking.

Ratio Evidence:

metabolites unrelated

Gene Ratio Phenotype Relationship:

The SLC17A4 missense variant may alter its function as a transporter for urate and other organic anions, potentially influencing uric acid levels and red blood cell parameters like MCH, MCHC, and hemoglobin, as suggested by the associated phenotypes.5[1], 1[2], 3[3], 4[4], 6[5], 7[6], 12[7]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data