palmitoylcarnitine (c16) to margarate (17:0)

Numerator Metabolite

Structure of palmitoylcarnitine (c16)
Metabolite Accession: GCST90199666
Name: palmitoylcarnitine (c16)
Hmdb Id: HMDB0000222
Super Pathway: NA
Sub Pathway: NA
Inchikey: XOMRRQXKHMYMOC

Denominator Metabolite

Structure of margarate (17:0)
Metabolite Accession: GCST90200459
Name: margarate (17:0)
Hmdb Id: HMDB0002259
Super Pathway: NA
Sub Pathway: NA
Inchikey: KEMQGTRYUADPNZ

Associated Genomic Regions

Region: rs274561

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
0.160
Position:
131719228
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
9.858
Reference Allele:
C
-log10(P):
-51.114
MAF:
0.372
Beta (Num):
0.116
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.044
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 C5orf56 SLC22A4 P4HA2 IRF1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation, Carnitine shuttle.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid metabolism.

Ratio Explanation:

The ratio reflects carnitine-dependent long-chain fatty acid transport (palmitoylcarnitine) relative to an odd-chain fatty acid (margarate), indicating altered mitochondrial fatty acid oxidation capacity.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 function can impair fatty acid oxidation, leading to altered energy metabolism and inflammatory responses. This dysfunction is linked to hyperuricemia and gout, as carnitine metabolism influences uric acid levels and inflammatory pathways, potentially affecting hematological traits.7[1], 8[2], 9[3], 10[4]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data