Infomap Cluster 115

Metabolite Network

mQTL individually significant in locus
Novel rQTL
Known rQTL

Aggregated Cluster Evidence

Significant GTEx eQTL Colocalization (P-alpha < 5e-5)

Tissue Gene P(alpha) Associated Metabolites
Heart Left Ventricle NFATC3 1.10e-05 branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid*palmitoleoylcarnitine (c16:1)*
Whole Blood SLC7A6 1.54e-05 branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid*palmitoleoylcarnitine (c16:1)*
Thyroid PLA2G15 3.73e-05 branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid*palmitoleoylcarnitine (c16:1)*

Genomic Context

Displaying 57 SNPs on Chr 5 for Cluster 115.

Novel rQTL (▲)
Known rQTL (▲)

Cluster Summary

173

Metabolite Ratios (rQTLs)

85

Total Unique Metabolites

8

Unnamed Metabolites

Ratios in Cluster 115

Ratio Name Novel in Cluster Driven By
(2 or 3)-decenoate (10:1n7 or n8) to acetylcarnitine (c2) No
(s)-3-hydroxybutyrylcarnitine to glutamine conjugate of c6h10o2 (1)* Yes
(s)-3-hydroxybutyrylcarnitine to glutamine conjugate of c6h10o2 (2)* Yes
(s)-3-hydroxybutyrylcarnitine to glutamine conjugate of c7h12o2* Yes
(s)-3-hydroxybutyrylcarnitine to x-12101 Yes
10-heptadecenoate (17:1n7) to acetylcarnitine (c2) No
10-nonadecenoate (19:1n9) to acetylcarnitine (c2) No
10-nonadecenoate (19:1n9) to Hexanoylcarnitine No
10-nonadecenoate (19:1n9) to myristoylcarnitine (c14) No
10-undecenoate (11:1n1) to myristoylcarnitine (c14) No
3-hydroxybutyrate to acetylcarnitine (c2) No
3-hydroxyhexanoylcarnitine (1) to glutamine conjugate of c6h10o2 (1)* Yes
3-hydroxyhexanoylcarnitine (1) to glutamine conjugate of c6h10o2 (2)* Yes
3-hydroxyhexanoylcarnitine (1) to glutamine conjugate of c7h12o2* Yes
3-hydroxylaurate to acetylcarnitine (c2) No
3-hydroxyoleoylcarnitine to 10-nonadecenoate (19:1n9) No
3-hydroxyoleoylcarnitine to docosapentaenoate (n6 dpa; 22:5n6) No
3-hydroxyoleoylcarnitine to glutamine conjugate of c6h10o2 (1)* No
3-hydroxyoleoylcarnitine to glutamine conjugate of c6h10o2 (2)* No
3-hydroxyoleoylcarnitine to glutamine conjugate of c7h12o2* No
3-hydroxyoleoylcarnitine to margarate (17:0) No
5-dodecenoate (12:1n7) to myristoylcarnitine (c14) No
acetylcarnitine (c2) to 3-hydroxymyristate No
acetylcarnitine (c2) to Docosahexaenoate DHA; 22:6n3 No
acetylcarnitine (c2) to margarate (17:0) No
acetylcarnitine (c2) to myristate (14:0) No
acetylcarnitine (c2) to palmitate (16:0) No
acetylcarnitine (c2) to palmitoleate (16:1n7) No
acetylcarnitine (c2) to stearate (18:0) No
adrenate (22:4n6) to 3-hydroxyoleoylcarnitine No
adrenate (22:4n6) to acetylcarnitine (c2) No
adrenate (22:4n6) to Hexanoylcarnitine No
adrenate (22:4n6) to myristoleoylcarnitine (c14:1)* Yes
adrenate (22:4n6) to myristoylcarnitine (c14) No
adrenate (22:4n6) to oleoylcarnitine (c18:1) No
adrenate (22:4n6) to palmitoleoylcarnitine (c16:1)* Yes
adrenate (22:4n6) to palmitoylcarnitine (c16) No
arachidonate (20:4n6) to (r)-3-hydroxybutyrylcarnitine Yes
arachidonate (20:4n6) to 3-hydroxyoleoylcarnitine No
arachidonate (20:4n6) to acetylcarnitine (c2) No
arachidonate (20:4n6) to dihomo-linoleoylcarnitine (c20:2)* No
arachidonate (20:4n6) to Hexanoylcarnitine No
arachidonate (20:4n6) to linolenoylcarnitine (c18:3)* No
arachidonate (20:4n6) to myristoleoylcarnitine (c14:1)* Yes
arachidonate (20:4n6) to myristoylcarnitine (c14) No
arachidonate (20:4n6) to oleoylcarnitine (c18:1) No
arachidonate (20:4n6) to palmitoleoylcarnitine (c16:1)* Yes
arachidonate (20:4n6) to palmitoylcarnitine (c16) No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to 3-hydroxyoleoylcarnitine No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to acetylcarnitine (c2) No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to myristoleoylcarnitine (c14:1)* Yes
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to oleoylcarnitine (c18:1) No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to palmitoleoylcarnitine (c16:1)* Yes
butyrylcarnitine (c4) to ethylmalonate Yes
carnitine C18:2 to dodecadienoate (12:2)* No
carnitine C18:2 to x-21319 No
cerotoylcarnitine (c26)* to tryptophan betaine No
cis 3,4-methyleneheptanoate to (s)-3-hydroxybutyrylcarnitine Yes
cis-3,4-methyleneheptanoylcarnitine to (s)-3-hydroxybutyrylcarnitine Yes
cis-3,4-methyleneheptanoylcarnitine to carnitine C18:2 No
cis-3,4-methyleneheptanoylcarnitine to linolenoylcarnitine (c18:3)* No
cis-3,4-methyleneheptanoylcarnitine to oleoylcarnitine (c18:1) No
dihomo-linoleate (20:2n6) to 3-hydroxyoleoylcarnitine No
dihomo-linoleate (20:2n6) to acetylcarnitine (c2) No
dihomo-linoleate (20:2n6) to Hexanoylcarnitine No
dihomo-linoleate (20:2n6) to myristoleoylcarnitine (c14:1)* Yes
dihomo-linoleate (20:2n6) to oleoylcarnitine (c18:1) No
dihomo-linoleate (20:2n6) to palmitoleoylcarnitine (c16:1)* Yes
dihomo-linolenate (20:3n3 or n6) to 3-hydroxyoleoylcarnitine No
dihomo-linolenate (20:3n3 or n6) to acetylcarnitine (c2) No
dihomo-linolenate (20:3n3 or n6) to myristoleoylcarnitine (c14:1)* Yes
dihomo-linolenate (20:3n3 or n6) to myristoylcarnitine (c14) No
dihomo-linolenate (20:3n3 or n6) to oleoylcarnitine (c18:1) No
dihomo-linolenate (20:3n3 or n6) to palmitoleoylcarnitine (c16:1)* Yes
docosadienoate (22:2n6) to acetylcarnitine (c2) No
docosadienoate (22:2n6) to oleoylcarnitine (c18:1) No
docosadienoate (22:2n6) to palmitoleoylcarnitine (c16:1)* Yes
docosahexaenoylcarnitine (c22:6)* to Docosahexaenoate DHA; 22:6n3 Yes
docosapentaenoate (n6 dpa; 22:5n6) to acetylcarnitine (c2) No
docosapentaenoate (n6 dpa; 22:5n6) to myristoylcarnitine (c14) No
docosapentaenoate (n6 dpa; 22:5n6) to oleoylcarnitine (c18:1) No
docosapentaenoate (n6 dpa; 22:5n6) to palmitoylcarnitine (c16) No
docosapentaenoate n3 DPA; 22:5n3 to (r)-3-hydroxybutyrylcarnitine Yes
docosapentaenoate n3 DPA; 22:5n3 to 3-hydroxyoleoylcarnitine No
docosapentaenoate n3 DPA; 22:5n3 to acetylcarnitine (c2) No
docosapentaenoate n3 DPA; 22:5n3 to Hexanoylcarnitine No
docosapentaenoate n3 DPA; 22:5n3 to laurylcarnitine Yes
docosapentaenoate n3 DPA; 22:5n3 to linolenoylcarnitine (c18:3)* No
docosapentaenoate n3 DPA; 22:5n3 to myristoleoylcarnitine (c14:1)* Yes
docosapentaenoate n3 DPA; 22:5n3 to myristoylcarnitine (c14) No
docosapentaenoate n3 DPA; 22:5n3 to oleoylcarnitine (c18:1) No
docosapentaenoate n3 DPA; 22:5n3 to palmitoleoylcarnitine (c16:1)* Yes
docosapentaenoate n3 DPA; 22:5n3 to palmitoylcarnitine (c16) No
dodecadienoate (12:2)* to acetylcarnitine (c2) No
dodecadienoate (12:2)* to oleoylcarnitine (c18:1) No
dodecadienoate (12:2)* to palmitoleoylcarnitine (c16:1)* Yes
eicosapentaenoate (epa; 20:5n3) to acetylcarnitine (c2) No
eicosapentaenoate (epa; 20:5n3) to docosahexaenoylcarnitine (c22:6)* Yes
eicosapentaenoate (epa; 20:5n3) to linolenoylcarnitine (c18:3)* No
eicosapentaenoate (epa; 20:5n3) to oleoylcarnitine (c18:1) No
eicosapentaenoate (epa; 20:5n3) to palmitoleoylcarnitine (c16:1)* Yes
eicosapentaenoate (epa; 20:5n3) to palmitoylcarnitine (c16) No
eicosenoate (20:1) to acetylcarnitine (c2) No
ergothioneine to 3-hydroxyoleoylcarnitine No
ergothioneine to acetylcarnitine (c2) No
ergothioneine to arachidoylcarnitine (c20)* No
ergothioneine to beta-hydroxyisovaleroylcarnitine No
ergothioneine to carnitine No
ergothioneine to carnitine C18:2 No
ergothioneine to cerotoylcarnitine (c26)* Yes
ergothioneine to dihomo-linoleoylcarnitine (c20:2)* No
ergothioneine to eicosenoylcarnitine (c20:1)* No
ergothioneine to homostachydrine* No
ergothioneine to isovalerylcarnitine (c5) Yes
ergothioneine to lignoceroylcarnitine (c24)* Yes
ergothioneine to myristoylcarnitine (c14) No
ergothioneine to n,n,n-trimethyl-5-aminovalerate No
ergothioneine to nervonoylcarnitine (c24:1)* No
ergothioneine to oleoylcarnitine (c18:1) No
ergothioneine to palmitoylcarnitine (c16) No
ergothioneine to stearoylcarnitine (c18) No
ergothioneine to tiglylcarnitine (c5:1-dc) No
ergothioneine to x-11381 No
ergothioneine to x-24241 No
ergothioneine to ximenoylcarnitine (c26:1)* No
glutamine conjugate of c6h10o2 (1)* to acetylcarnitine (c2) No
glutamine conjugate of c6h10o2 (1)* to myristoylcarnitine (c14) No
glutamine conjugate of c6h10o2 (1)* to oleoylcarnitine (c18:1) No
glutamine conjugate of c6h10o2 (1)* to palmitoleoylcarnitine (c16:1)* Yes
glutamine conjugate of c6h10o2 (2)* to acetylcarnitine (c2) No
glutamine conjugate of c6h10o2 (2)* to linolenoylcarnitine (c18:3)* No
glutamine conjugate of c6h10o2 (2)* to myristoylcarnitine (c14) No
glutamine conjugate of c6h10o2 (2)* to oleoylcarnitine (c18:1) No
glutamine conjugate of c6h10o2 (2)* to palmitoleoylcarnitine (c16:1)* Yes
glutamine conjugate of c7h12o2* to acetylcarnitine (c2) No
glutamine conjugate of c7h12o2* to myristoylcarnitine (c14) No
glutamine conjugate of c7h12o2* to oleoylcarnitine (c18:1) No
glutamine conjugate of c7h12o2* to palmitoleoylcarnitine (c16:1)* Yes
hexadecadienoate (16:2n6) to acetylcarnitine (c2) No
hexadecadienoate (16:2n6) to oleoylcarnitine (c18:1) No
hexadecadienoate (16:2n6) to palmitoleoylcarnitine (c16:1)* Yes
hexanoylglutamine to acetylcarnitine (c2) No
histidine betaine (hercynine)* to acetylcarnitine (c2) No
histidine betaine (hercynine)* to arachidoylcarnitine (c20)* No
histidine betaine (hercynine)* to cerotoylcarnitine (c26)* No
histidine betaine (hercynine)* to lignoceroylcarnitine (c24)* No
histidine betaine (hercynine)* to linolenoylcarnitine (c18:3)* No
histidine betaine (hercynine)* to margaroylcarnitine (c17)* No
histidine betaine (hercynine)* to nervonoylcarnitine (c24:1)* No
histidine betaine (hercynine)* to x-11381 No
histidine betaine (hercynine)* to x-24241 No
isovalerylcarnitine (c5) to valine No
lignoceroylcarnitine (c24)* to tryptophan betaine No
linoleate (18:2n6) to acetylcarnitine (c2) No
linoleate (18:2n6) to oleoylcarnitine (c18:1) No
linoleate (18:2n6) to palmitoleoylcarnitine (c16:1)* Yes
linolenate [alpha or gamma; (18:3n3 or 6)] to acetylcarnitine (c2) No
linolenoylcarnitine (c18:3)* to linolenate [alpha or gamma; (18:3n3 or 6)] No Numerator
linolenoylcarnitine (c18:3)* to x-11478 No
linolenoylcarnitine (c18:3)* to x-15486 No
margarate (17:0) to Hexanoylcarnitine No
margaroylcarnitine (c17)* to tridecenedioate (c13:1-dc)* No
myristoleate (14:1n5) to myristoylcarnitine (c14) No
myristoleate (14:1n5) to oleoylcarnitine (c18:1) No
myristoleate (14:1n5) to palmitoleoylcarnitine (c16:1)* Yes
myristoleoylcarnitine (c14:1)* to docosapentaenoate (n6 dpa; 22:5n6) Yes
myristoleoylcarnitine (c14:1)* to dodecadienoate (12:2)* Yes
myristoleoylcarnitine (c14:1)* to glutamine conjugate of c6h10o2 (1)* Yes
myristoleoylcarnitine (c14:1)* to glutamine conjugate of c6h10o2 (2)* Yes
myristoleoylcarnitine (c14:1)* to glutamine conjugate of c7h12o2* Yes
myristoleoylcarnitine (c14:1)* to hexadecadienoate (16:2n6) Yes
myristoleoylcarnitine (c14:1)* to tetradecadienoate (14:2)* Yes
myristoylcarnitine (c14) to 10-heptadecenoate (17:1n7) No
myristoylcarnitine (c14) to margarate (17:0) No
myristoylcarnitine (c14) to myristate (14:0) No
myristoylcarnitine (c14) to palmitate (16:0) No
myristoylcarnitine (c14) to pentadecanoate (15:0) No
oleate/vaccenate (18:1) to 3-hydroxyoleoylcarnitine No
oleate/vaccenate (18:1) to acetylcarnitine (c2) No
oleate/vaccenate (18:1) to oleoylcarnitine (c18:1) No
oleate/vaccenate (18:1) to palmitoleoylcarnitine (c16:1)* Yes
oleoylcarnitine (c18:1) to 10-heptadecenoate (17:1n7) No
oleoylcarnitine (c18:1) to 10-nonadecenoate (19:1n9) No
oleoylcarnitine (c18:1) to Docosahexaenoate DHA; 22:6n3 No
oleoylcarnitine (c18:1) to eicosenoate (20:1) No
oleoylcarnitine (c18:1) to margarate (17:0) No
oleoylcarnitine (c18:1) to palmitate (16:0) No
oleoylcarnitine (c18:1) to palmitoleate (16:1n7) No
oleoylcarnitine (c18:1) to stearidonate (18:4n3) No
palmitoleoylcarnitine (c16:1)* to 10-heptadecenoate (17:1n7) Yes
palmitoleoylcarnitine (c16:1)* to 10-nonadecenoate (19:1n9) Yes
palmitoleoylcarnitine (c16:1)* to 3-hydroxymyristate Yes
palmitoleoylcarnitine (c16:1)* to 5-dodecenoate (12:1n7) Yes
palmitoleoylcarnitine (c16:1)* to Docosahexaenoate DHA; 22:6n3 Yes
palmitoleoylcarnitine (c16:1)* to docosapentaenoate (n6 dpa; 22:5n6) Yes
palmitoleoylcarnitine (c16:1)* to margarate (17:0) Yes
palmitoleoylcarnitine (c16:1)* to palmitate (16:0) Yes
palmitoleoylcarnitine (c16:1)* to palmitoleate (16:1n7) Yes
palmitoleoylcarnitine (c16:1)* to stearidonate (18:4n3) Yes
palmitoylcarnitine (c16) to margarate (17:0) No
propionylcarnitine (c3) to ergothioneine No
stearidonate (18:4n3) to acetylcarnitine (c2) No
tetradecadienoate (14:2)* to acetylcarnitine (c2) No
tetradecadienoate (14:2)* to oleoylcarnitine (c18:1) No
tetradecadienoate (14:2)* to palmitoleoylcarnitine (c16:1)* Yes
tetradecanedioate (c14-dc) to myristoylcarnitine (c14) No
tridecenedioate (c13:1-dc)* to acetylcarnitine (c2) No
tridecenedioate (c13:1-dc)* to myristoylcarnitine (c14) No
tridecenedioate (c13:1-dc)* to palmitoylcarnitine (c16) No
x-18921 to linolenoylcarnitine (c18:3)* No
x-21319 to (s)-3-hydroxybutyrylcarnitine Yes
x-21319 to eicosenoylcarnitine (c20:1)* No
x-21319 to linolenoylcarnitine (c18:3)* No
x-21319 to oleoylcarnitine (c18:1) No