docosapentaenoate (n6 dpa; 22:5n6) to oleoylcarnitine (c18:1)

Numerator Metabolite

Structure of docosapentaenoate (n6 dpa; 22:5n6)
Metabolite Accession: GCST90199796
Name: docosapentaenoate (n6 dpa; 22:5n6)
Hmdb Id: HMDB0001976
Super Pathway: NA
Sub Pathway: NA
Inchikey: AVKOENOBFIYBSA

Denominator Metabolite

Metabolite Accession: GCST90199774
Name: NA
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs2631371

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.188
Position:
131703691
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
-10.352
Reference Allele:
G
-log10(P):
-56.149
MAF:
0.293
Beta (Num):
-0.059
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.129
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 SLC22A4 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Omega-6 fatty acid biosynthesis4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation7[1], 8[2]

Ratio Explanation:

The ratio reflects an imbalance between a polyunsaturated fatty acid (docosapentaenoate) and a product of incomplete fatty acid oxidation (oleoylcarnitine), potentially influenced by SLC22A5 function.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Altered SLC22A5 function likely impairs carnitine-dependent transport of fatty acids for beta-oxidation, leading to an accumulation of oleoylcarnitine and potentially affecting membrane lipid composition and hematopoietic processes, which could influence circulating blood cell counts.3[1], 9[2]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data