glutamine conjugate of c7h12o2* to oleoylcarnitine (c18:1)

Numerator Metabolite

Metabolite Accession: GCST90200167
Name: glutamine conjugate of c7h12o2*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90199774
Name: NA
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs272872

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Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.186
Position:
131675864
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
-10.545
Reference Allele:
G
-log10(P):
-58.189
MAF:
0.294
Beta (Num):
-0.056
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.130
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 SLC22A5 P4HA2 PDLIM4 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic metabolism, Glutamine conjugation

Denominator Metabolite Explanation:

Fatty acid oxidation, Carnitine shuttle

Ratio Explanation:

The ratio may reflect competition for the SLC22A5 transporter, which mediates carnitine transport (denominator) and potentially transports or is inhibited by other organic cations (numerator).5[1], 6[2], 7[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SLC22A5 function affects the transport of both oleoylcarnitine and potentially the glutamine conjugate, impacting carnitine-dependent energy metabolism, which is critical for all cells, including hematopoietic cells, thereby influencing neutrophil, platelet, and other blood cell counts observed in the phenotype.3[1], 8[2]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data