linolenate [alpha or gamma; (18:3n3 or 6)] to acetylcarnitine (c2)

Numerator Metabolite

Structure of linolenate [alpha or gamma; (18:3n3 or 6)]
Metabolite Accession: GCST90199748
Name: linolenate [alpha or gamma; (18:3n3 or 6)]
Hmdb Id: HMDB0003073,HMDB0001388
Super Pathway: NA
Sub Pathway: NA
Inchikey: DTOSIQBPPRVQHS

Denominator Metabolite

Structure of acetylcarnitine (c2)
Metabolite Accession: GCST90199669
Name: acetylcarnitine (c2)
Hmdb Id: HMDB0000201
Super Pathway: NA
Sub Pathway: NA
Inchikey: RDHQFKQIGNGIED

Associated Genomic Regions

Region: rs272849

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
5
Beta (Ratio):
-0.151
Position:
131690241
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
-9.553
Reference Allele:
G
-log10(P):
-48.128
MAF:
0.373
Beta (Num):
-0.039
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.112
SE (Den):
0.015
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 SLC22A5 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis/metabolism.6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle.9[1], 10[2], 11[3]

Ratio Explanation:

This ratio may reflect the balance between fatty acid availability (linolenate) and its transport for mitochondrial oxidation, a process dependent on carnitine transporters like SLC22A4/5.1[1], 12[2], 13[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in SLC22A4, an inflammation-associated gene3[1], 4[2], 14[3], likely alters transporter function. This impacts the balance of linolenate and acetylcarnitine, which is linked to changes in immune cell counts (neutrophils, eosinophils, etc.), common inflammatory biomarkers.

Phenotype Driver:

Gene-centric:SLC22A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data