dodecadienoate (12:2)* to palmitoleoylcarnitine (c16:1)*

Numerator Metabolite

Metabolite Accession: GCST90200190
Name: dodecadienoate (12:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of palmitoleoylcarnitine (c16:1)*
Metabolite Accession: GCST90200110
Name: palmitoleoylcarnitine (c16:1)*
Hmdb Id: HMDB0240782
Super Pathway: NA
Sub Pathway: NA
Inchikey: JFAGPSOZZSTLRF

Associated Genomic Regions

Region: rs2999545

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.171
Position:
151904146
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
-12.222
Reference Allele:
T
-log10(P):
-77.421
MAF:
0.388
Beta (Num):
-0.116
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.055
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D RORC

Region: rs151154986

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.637
Position:
74040136
SE (Ratio):
0.040
Effect Allele:
A
Z-score (Ratio):
-15.900
Reference Allele:
G
-log10(P):
-129.403
MAF:
0.030
Beta (Num):
-0.605
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
0.032
SE (Den):
0.042
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

Region: rs200837

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Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.130
Position:
131699958
SE (Ratio):
0.015
Effect Allele:
G
Z-score (Ratio):
-8.698
Reference Allele:
A
-log10(P):
-40.230
MAF:
0.294
Beta (Num):
-0.039
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.092
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 SLC22A4 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.5[1]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle.6[1], 7[2]

Ratio Explanation:

The ratio may represent the balance between mitochondrial fatty acid degradation and their transport for beta-oxidation, a process influenced by ACOT2's role in regulating acyl-CoA levels.3[1], 8[2], 9[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered ACOT2 function can impact mitochondrial lipid metabolism and energy homeostasis.10[1], 11[2] This systemic effect on cellular processes could influence the development and maturation of hematopoietic cells, leading to the observed variations in monocyte, platelet, and other blood cell counts.12[3], 13[4]

Phenotype Driver:

Gene-centric:ACOT2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data