Infomap Cluster 44

Metabolite Network

mQTL individually significant in locus
Novel rQTL
Known rQTL

Aggregated Cluster Evidence

Significant GTEx eQTL Colocalization (P-alpha < 5e-5)

Tissue Gene P(alpha) Associated Metabolites
Heart Left Ventricle NFATC3 1.10e-05 (2 or 3)-decenoate (10:1n7 or n8)10-nonadecenoate (19:1n9)
Whole Blood SLC7A6 1.54e-05 (2 or 3)-decenoate (10:1n7 or n8)10-nonadecenoate (19:1n9)
Thyroid PLA2G15 3.73e-05 (2 or 3)-decenoate (10:1n7 or n8)10-nonadecenoate (19:1n9)

Genomic Context

Displaying 4 SNPs on Chr 14 for Cluster 44.

Novel rQTL (▲)
Known rQTL (▲)

Cluster Summary

104

Metabolite Ratios (rQTLs)

49

Total Unique Metabolites

2

Unnamed Metabolites

Ratios in Cluster 44

Ratio Name Novel in Cluster Driven By
(2 or 3)-decenoate (10:1n7 or n8) to 10-heptadecenoate (17:1n7) No
(2 or 3)-decenoate (10:1n7 or n8) to 10-nonadecenoate (19:1n9) No
(2 or 3)-decenoate (10:1n7 or n8) to 3-hydroxybutyrate No
(2 or 3)-decenoate (10:1n7 or n8) to 3-hydroxydecanoate No
(2 or 3)-decenoate (10:1n7 or n8) to 3-hydroxylaurate No
(2 or 3)-decenoate (10:1n7 or n8) to 3-hydroxymyristate No
(2 or 3)-decenoate (10:1n7 or n8) to adrenate (22:4n6) No
(2 or 3)-decenoate (10:1n7 or n8) to cis-4-decenoate (10:1n6)* No
(2 or 3)-decenoate (10:1n7 or n8) to dihomo-linoleate (20:2n6) No
(2 or 3)-decenoate (10:1n7 or n8) to dihomo-linolenate (20:3n3 or n6) No
(2 or 3)-decenoate (10:1n7 or n8) to docosadienoate (22:2n6) No
(2 or 3)-decenoate (10:1n7 or n8) to Docosahexaenoate DHA; 22:6n3 No
(2 or 3)-decenoate (10:1n7 or n8) to docosapentaenoate (n6 dpa; 22:5n6) No
(2 or 3)-decenoate (10:1n7 or n8) to docosapentaenoate n3 DPA; 22:5n3 No
(2 or 3)-decenoate (10:1n7 or n8) to eicosenoate (20:1) No
(2 or 3)-decenoate (10:1n7 or n8) to glycerol No
(2 or 3)-decenoate (10:1n7 or n8) to linoleate (18:2n6) No
(2 or 3)-decenoate (10:1n7 or n8) to linolenate [alpha or gamma; (18:3n3 or 6)] No
(2 or 3)-decenoate (10:1n7 or n8) to margarate (17:0) No
(2 or 3)-decenoate (10:1n7 or n8) to oleate/vaccenate (18:1) No
(2 or 3)-decenoate (10:1n7 or n8) to palmitate (16:0) No
(2 or 3)-decenoate (10:1n7 or n8) to palmitoleate (16:1n7) No
(2 or 3)-decenoate (10:1n7 or n8) to stearate (18:0) No
(2 or 3)-decenoate (10:1n7 or n8) to stearidonate (18:4n3) No
(2 or 3)-decenoate (10:1n7 or n8) to x-21353 No
(2 or 3)-decenoate (10:1n7 or n8) to x-23782 No
3-hydroxybutyrate to dodecadienoate (12:2)* No
3-hydroxydecanoylcarnitine to (2 or 3)-decenoate (10:1n7 or n8) No
3-hydroxydecanoylcarnitine to branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* No
3-hydroxydecanoylcarnitine to dodecadienoate (12:2)* No
3-hydroxylaurate to dodecadienoate (12:2)* No
3-hydroxyoctanoylcarnitine (1) to dodecadienoate (12:2)* No
adrenate (22:4n6) to dodecadienoate (12:2)* No
arachidonate (20:4n6) to dodecadienoate (12:2)* No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to (16 or 17)-methylstearate (a19:0 or i19:0) No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to 10-heptadecenoate (17:1n7) No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to 10-nonadecenoate (19:1n9) No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to 3-hydroxybutyrate No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to 3-hydroxydecanoate No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to 3-hydroxylaurate No Numerator
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to 3-hydroxymyristate No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to 3-hydroxyoctanoylcarnitine (1) No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to 3-hydroxyoctanoylcarnitine (2) No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to 5-dodecenoate (12:1n7) No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to 5-dodecenoylcarnitine (c12:1) No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to acetylcarnitine (c2) No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to adrenate (22:4n6) No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to arachidonate (20:4n6) No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to cis-4-decenoate (10:1n6)* No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to decanoylcarnitine (c10) No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to dihomo-linoleate (20:2n6) No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to dihomo-linolenate (20:3n3 or n6) No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to docosadienoate (22:2n6) No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to Docosahexaenoate DHA; 22:6n3 No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to docosapentaenoate (n6 dpa; 22:5n6) No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to docosapentaenoate n3 DPA; 22:5n3 No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to eicosenoate (20:1) No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to glycerol No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to hexadecadienoate (16:2n6) No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to laurylcarnitine No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to linoleate (18:2n6) No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to linolenate [alpha or gamma; (18:3n3 or 6)] No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to margarate (17:0) No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to myristate (14:0) No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to myristoleate (14:1n5) No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to myristoleoylcarnitine (c14:1)* No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to octanoylcarnitine (c8) No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to oleate/vaccenate (18:1) No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to palmitate (16:0) No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to palmitoleate (16:1n7) No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to palmitoleoylcarnitine (c16:1)* No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to pentadecanoate (15:0) No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to stearate (18:0) No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to stearidonate (18:4n3) No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to tetradecadienoate (14:2)* No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to x-21353 No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to x-23782 No
cis-4-decenoate (10:1n6)* to dodecadienoate (12:2)* No
cis-4-decenoylcarnitine (c10:1) to dodecadienoate (12:2)* No
dihomo-linoleate (20:2n6) to dodecadienoate (12:2)* No
dihomo-linolenate (20:3n3 or n6) to dodecadienoate (12:2)* No
docosadienoate (22:2n6) to dodecadienoate (12:2)* No
docosapentaenoate n3 DPA; 22:5n3 to dodecadienoate (12:2)* No
dodecadienoate (12:2)* to 10-heptadecenoate (17:1n7) No
dodecadienoate (12:2)* to 10-nonadecenoate (19:1n9) No
dodecadienoate (12:2)* to 3-hydroxydecanoate No
dodecadienoate (12:2)* to 3-hydroxymyristate No
dodecadienoate (12:2)* to decanoylcarnitine (c10) No
dodecadienoate (12:2)* to Docosahexaenoate DHA; 22:6n3 No
dodecadienoate (12:2)* to docosapentaenoate (n6 dpa; 22:5n6) No
dodecadienoate (12:2)* to eicosenoate (20:1) No
dodecadienoate (12:2)* to hexadecadienoate (16:2n6) No
dodecadienoate (12:2)* to linolenate [alpha or gamma; (18:3n3 or 6)] No
dodecadienoate (12:2)* to margarate (17:0) No
dodecadienoate (12:2)* to myristate (14:0) No
dodecadienoate (12:2)* to octanoylcarnitine (c8) No
dodecadienoate (12:2)* to palmitate (16:0) No
dodecadienoate (12:2)* to palmitoleate (16:1n7) No
dodecadienoate (12:2)* to palmitoleoylcarnitine (c16:1)* No
dodecadienoate (12:2)* to stearate (18:0) No
dodecadienoate (12:2)* to stearidonate (18:4n3) No
dodecadienoate (12:2)* to x-23782 No
glycerol to dodecadienoate (12:2)* No
linoleate (18:2n6) to dodecadienoate (12:2)* No
myristoleate (14:1n5) to dodecadienoate (12:2)* No
myristoleoylcarnitine (c14:1)* to dodecadienoate (12:2)* No
oleate/vaccenate (18:1) to dodecadienoate (12:2)* No
tetradecadienoate (14:2)* to dodecadienoate (12:2)* No
undecenoylcarnitine (c11:1) to dodecadienoate (12:2)* No
x-21353 to dodecadienoate (12:2)* No
x-21353 to tetradecadienoate (14:2)* Yes