docosapentaenoate n3 DPA; 22:5n3 to dodecadienoate (12:2)*

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Metabolite Accession: GCST90200190
Name: dodecadienoate (12:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs28415528

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.132
Position:
151879761
SE (Ratio):
0.013
Effect Allele:
A
Z-score (Ratio):
9.799
Reference Allele:
G
-log10(P):
-50.530
MAF:
0.318
Beta (Num):
0.017
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.115
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

Region: rs148925835

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
0.467
Position:
73282698
SE (Ratio):
0.061
Effect Allele:
G
Z-score (Ratio):
7.601
Reference Allele:
T
-log10(P):
-31.159
MAF:
0.010
Beta (Num):
0.088
Novel Locus:
Yes ✔️
SE (Num):
0.073
Beta (Den):
-0.379
SE (Den):
0.073
No CNV overlap
rQTL cluster:
45
Reaction Distance:
NA
Closest Genes:
DPF3 DCAF4 ZFYVE1 RBM25 RGS6

Region: rs151154986

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
0.637
Position:
74040136
SE (Ratio):
0.037
Effect Allele:
A
Z-score (Ratio):
17.396
Reference Allele:
G
-log10(P):
-154.403
MAF:
0.030
Beta (Num):
0.032
Novel Locus:
No
SE (Num):
0.043
Beta (Den):
-0.605
SE (Den):
0.044
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Long-chain polyunsaturated fatty acid biosynthesis.8[1], 9[2], 10[3]

Denominator Metabolite Explanation:

Fatty acid metabolism, beta-oxidation.11[1], 12[2], 13[3]

Ratio Explanation:

The ratio reflects the balance between long-chain omega-3 fatty acid (DPA) synthesis, influenced by FADS enzymes, and acyl-CoA metabolism, regulated by ACOT2.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in the FADS gene cluster and ACOT2 alters fatty acid metabolism. This can influence the risk for lipid-related disorders like hypercholesterolemia and cholelithiasis, and inflammatory conditions such as asthma, by changing the balance of pro- and anti-inflammatory fatty acids.14[1], 15[2], 16[3], 17[4], 18[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data