(2 or 3)-decenoate (10:1n7 or n8) to docosadienoate (22:2n6)

Numerator Metabolite

Metabolite Accession: GCST90200263
Name: (2 or 3)-decenoate (10:1n7 or n8)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of docosadienoate (22:2n6)
Metabolite Accession: GCST90199711
Name: docosadienoate (22:2n6)
Hmdb Id: HMDB0061714
Super Pathway: NA
Sub Pathway: NA
Inchikey: HVGRZDASOHMCSK

Associated Genomic Regions

Region: rs113665868

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.339
Position:
74035410
SE (Ratio):
0.034
Effect Allele:
A
Z-score (Ratio):
-10.005
Reference Allele:
T
-log10(P):
-52.592
MAF:
0.040
Beta (Num):
-0.248
Novel Locus:
No
SE (Num):
0.038
Beta (Den):
0.091
SE (Den):
0.039
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation.3[1]

Denominator Metabolite Explanation:

Fatty acid biosynthesis and beta-oxidation.4[1], 5[2]

Ratio Explanation:

The ratio of medium-chain (2 or 3)-decenoate to very-long-chain docosadienoate may reflect Acyl-CoA thioesterase (ACOT) activity, influencing the balance of fatty acid chain lengths.6[1], 7[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

No associated phenotype was provided; therefore, a link between the ACOT gene-driven ratio of medium- to very-long-chain fatty acids and a clinical outcome cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data