(2 or 3)-decenoate (10:1n7 or n8) to 3-hydroxybutyrate

Numerator Metabolite

Metabolite Accession: GCST90200263
Name: (2 or 3)-decenoate (10:1n7 or n8)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 3-hydroxybutyrate (bhba)
Metabolite Accession: GCST90200367
Name: 3-hydroxybutyrate (bhba)
Hmdb Id: HMDB0000011
Super Pathway: NA
Sub Pathway: NA
Inchikey: WHBMMWSBFZVSSR

Associated Genomic Regions

Region: rs113860908

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
14
Beta (Ratio):
-0.330
Position:
74070803
SE (Ratio):
0.033
Effect Allele:
G
Z-score (Ratio):
-10.160
Reference Allele:
A
-log10(P):
-54.164
MAF:
0.041
Beta (Num):
-0.255
Novel Locus:
No
SE (Num):
0.038
Beta (Den):
0.076
SE (Den):
0.038
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT6 ACOT4 ACOT2 DNAL1 HEATR4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation.4[1], 5[2]

Denominator Metabolite Explanation:

Ketogenesis, ketone body metabolism.6[1], 7[2], 8[3]

Ratio Explanation:

This ratio reflects the balance between an intermediate of unsaturated fatty acid oxidation (decenoate) and a product of fatty acid oxidation, the ketone body 3-hydroxybutyrate.6[1], 8[2], 5[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

No associated phenotype was provided; therefore, a causal link between the ECI2-driven metabolic ratio and a clinical outcome cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data