(2 or 3)-decenoate (10:1n7 or n8) to 3-hydroxydecanoate

Numerator Metabolite

Metabolite Accession: GCST90200263
Name: (2 or 3)-decenoate (10:1n7 or n8)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 3-hydroxydecanoate
Metabolite Accession: GCST90199693
Name: 3-hydroxydecanoate
Hmdb Id: HMDB0002203
Super Pathway: NA
Sub Pathway: NA
Inchikey: FYSSBMZUBSBFJL

Associated Genomic Regions

Region: rs28415528

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.187
Position:
151879761
SE (Ratio):
0.012
Effect Allele:
A
Z-score (Ratio):
16.215
Reference Allele:
G
-log10(P):
-134.479
MAF:
0.318
Beta (Num):
-0.023
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.210
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

Region: rs35259237

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.365
Position:
73890837
SE (Ratio):
0.046
Effect Allele:
A
Z-score (Ratio):
-7.909
Reference Allele:
C
-log10(P):
-33.588
MAF:
0.013
Beta (Num):
-0.357
Novel Locus:
No
SE (Num):
0.065
Beta (Den):
0.008
SE (Den):
0.064
No CNV overlap
rQTL cluster:
45
Reaction Distance:
NA
Closest Genes:
NUMB HEATR4 ACOT1 ACOT2 PAPLN

Region: rs151154986

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.396
Position:
74040136
SE (Ratio):
0.032
Effect Allele:
A
Z-score (Ratio):
-12.506
Reference Allele:
G
-log10(P):
-80.964
MAF:
0.029
Beta (Num):
-0.345
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
0.051
SE (Den):
0.044
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

Region: rs659305

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Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.150
Position:
4125655
SE (Ratio):
0.012
Effect Allele:
G
Z-score (Ratio):
12.936
Reference Allele:
A
-log10(P):
-86.466
MAF:
0.316
Beta (Num):
0.158
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.008
SE (Den):
0.016
No CNV overlap
rQTL cluster:
113
Reaction Distance:
NA
Closest Genes:
ECI2 C6orf201 FAM217A PRPF4B C6ORF50

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Fatty acid beta-oxidation

Ratio Explanation:

This ratio reflects the efficiency of the enoyl-CoA hydratase step in beta-oxidation, which is influenced by ECI2 activity on decenoyl-CoA isomers.5[1], 6[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in ECI2 influences the ratio of beta-oxidation intermediates; however, with no associated phenotype provided, a direct link cannot be established.3[1], 7[2]

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data