branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to 10-heptadecenoate (17:1n7)

Numerator Metabolite

Metabolite Accession: GCST90200249
Name: branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 10-heptadecenoate (17:1n7)
Metabolite Accession: GCST90199731
Name: 10-heptadecenoate (17:1n7)
Hmdb Id: HMDB0060038
Super Pathway: NA
Sub Pathway: NA
Inchikey: GDTXICBNEOEPAZ

Associated Genomic Regions

Region: rs147794363

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.369
Position:
73271372
SE (Ratio):
0.046
Effect Allele:
T
Z-score (Ratio):
-7.940
Reference Allele:
C
-log10(P):
-33.831
MAF:
0.011
Beta (Num):
-0.246
Novel Locus:
Yes ✔️
SE (Num):
0.069
Beta (Den):
0.123
SE (Den):
0.069
No CNV overlap
rQTL cluster:
45
Reaction Distance:
NA
Closest Genes:
DPF3 DCAF4 ZFYVE1 RGS6 RBM25

Region: rs151154986

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.505
Position:
74040136
SE (Ratio):
0.029
Effect Allele:
A
Z-score (Ratio):
-17.323
Reference Allele:
G
-log10(P):
-153.128
MAF:
0.029
Beta (Num):
-0.480
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
0.025
SE (Den):
0.043
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis and β-oxidation. 3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid β-oxidation and metabolism.

Ratio Explanation:

5[1] The ratio reflects the relative activity of ACOT enzymes on different chain-length fatty acids, potentially indicating shifts in mitochondrial lipid metabolism.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data