branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to tetradecadienoate (14:2)*

Numerator Metabolite

Metabolite Accession: GCST90200249

Name: branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid*

Hmdb Id: NA

Super Pathway: NA

Sub Pathway: NA

Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200187

Name: tetradecadienoate (14:2)*

Hmdb Id: HMDB0000560

Super Pathway: NA

Sub Pathway: NA

Inchikey: HXHZGHRLVRFQDR

Associated Genomic Regions

Region: rs9943251

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:

Beta (Ratio):

0.120

Position:

151917115

SE (Ratio):

0.008

Effect Allele:

Z-score (Ratio):

15.688

Reference Allele:

-log10(P):

-126.044

MAF:

0.315

Beta (Num):

-4.61e-04

Novel Locus:

SE (Num):

0.016

Beta (Den):

-0.120

SE (Den):

0.016

No CNV overlap

rQTL cluster:

155

Reaction Distance:

Closest Genes:

THEM4 S100A10 S100A11 THEM5 C2CD4D

Region: rs151154986

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:

Beta (Ratio):

-0.314

Position:

74040136

SE (Ratio):

0.021

Effect Allele:

Z-score (Ratio):

-15.086

Reference Allele:

-log10(P):

-116.737

MAF:

0.029

Beta (Num):

-0.480

Novel Locus:

SE (Num):

0.044

Beta (Den):

-0.166

SE (Den):

0.043

No CNV overlap

rQTL cluster:

Reaction Distance:

Closest Genes:

ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism/biosynthesis

Denominator Metabolite Explanation:

Fatty acid metabolism/oxidation

Ratio Explanation:

The ratio may reflect ACOT2 activity, which can hydrolyze various fatty acyl-CoAs, including C12 and C14 chain lengths, influencing their relative abundance.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No phenotype is provided, so a link cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data