dodecadienoate (12:2)* to docosapentaenoate (n6 dpa; 22:5n6)

Numerator Metabolite

Metabolite Accession: GCST90200190
Name: dodecadienoate (12:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of docosapentaenoate (n6 dpa; 22:5n6)
Metabolite Accession: GCST90199796
Name: docosapentaenoate (n6 dpa; 22:5n6)
Hmdb Id: HMDB0001976
Super Pathway: NA
Sub Pathway: NA
Inchikey: AVKOENOBFIYBSA

Associated Genomic Regions

Region: rs174570

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.204
Position:
61597212
SE (Ratio):
0.022
Effect Allele:
T
Z-score (Ratio):
9.411
Reference Allele:
C
-log10(P):
-46.766
MAF:
0.131
Beta (Num):
0.042
Novel Locus:
No
SE (Num):
0.022
Beta (Den):
-0.162
SE (Den):
0.023
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

Region: rs151154986

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.680
Position:
74040136
SE (Ratio):
0.043
Effect Allele:
A
Z-score (Ratio):
-15.682
Reference Allele:
G
-log10(P):
-125.939
MAF:
0.030
Beta (Num):
-0.605
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
0.075
SE (Den):
0.046
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis and beta-oxidation.6[1]

Denominator Metabolite Explanation:

Omega-6 polyunsaturated fatty acid biosynthesis.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio of dodecadienoate to docosapentaenoate may reflect the efficiency of the FADS2-mediated pathway for synthesizing long-chain polyunsaturated fatty acids.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in FADS2 can alter its enzymatic activity, which changes the profile of polyunsaturated fatty acids as reflected by the ratio. This dysregulation can impact membrane composition and inflammatory signaling, plausibly contributing to an altered risk for Type 2 diabetes and non-melanoma skin cancer.10[1], 11[2], 12[3], 13[4]

Phenotype Driver:

Gene-centric:[FADS2]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data