(2 or 3)-decenoate (10:1n7 or n8) to 3-hydroxylaurate

Numerator Metabolite

Metabolite Accession: GCST90200263
Name: (2 or 3)-decenoate (10:1n7 or n8)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 3-hydroxylaurate
Metabolite Accession: GCST90199700
Name: 3-hydroxylaurate
Hmdb Id: HMDB0000387
Super Pathway: NA
Sub Pathway: NA
Inchikey: MUCMKTPAZLSKTL

Associated Genomic Regions

Region: rs35259237

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.341
Position:
73890837
SE (Ratio):
0.041
Effect Allele:
A
Z-score (Ratio):
-8.360
Reference Allele:
C
-log10(P):
-37.304
MAF:
0.013
Beta (Num):
-0.357
Novel Locus:
No
SE (Num):
0.065
Beta (Den):
-0.016
SE (Den):
0.065
No CNV overlap
rQTL cluster:
45
Reaction Distance:
NA
Closest Genes:
NUMB HEATR4 ACOT1 ACOT2 PAPLN

Region: rs151154986

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.332
Position:
74040136
SE (Ratio):
0.028
Effect Allele:
A
Z-score (Ratio):
-11.908
Reference Allele:
G
-log10(P):
-73.609
MAF:
0.029
Beta (Num):
-0.345
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
-0.013
SE (Den):
0.044
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

Region: rs676683

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.132
Position:
4127253
SE (Ratio):
0.010
Effect Allele:
T
Z-score (Ratio):
12.948
Reference Allele:
C
-log10(P):
-86.612
MAF:
0.316
Beta (Num):
0.158
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.026
SE (Den):
0.016
No CNV overlap
rQTL cluster:
113
Reaction Distance:
NA
Closest Genes:
ECI2 C6orf201 FAM217A PRPF4B C6ORF50

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation, Fatty acid biosynthesis.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.6[1]

Ratio Explanation:

The ratio may reflect the balance between steps in fatty acid beta-oxidation, potentially influenced by ECI2 and ACOT2 activities on their respective substrates.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data