branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to dihomo-linolenate (20:3n3 or n6)

Numerator Metabolite

Metabolite Accession: GCST90200249
Name: branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of dihomo-linolenate (20:3n3 or n6)
Metabolite Accession: GCST90199820
Name: dihomo-linolenate (20:3n3 or n6)
Hmdb Id: HMDB0002925
Super Pathway: NA
Sub Pathway: NA
Inchikey: AHANXAKGNAKFSK

Associated Genomic Regions

Region: rs61896141

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.172
Position:
61556039
SE (Ratio):
0.016
Effect Allele:
C
Z-score (Ratio):
-11.003
Reference Allele:
A
-log10(P):
-63.165
MAF:
0.179
Beta (Num):
-0.023
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.149
SE (Den):
0.020
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

Region: rs151154986

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.517
Position:
74040136
SE (Ratio):
0.035
Effect Allele:
A
Z-score (Ratio):
-14.742
Reference Allele:
G
-log10(P):
-111.578
MAF:
0.029
Beta (Num):
-0.480
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
0.038
SE (Den):
0.044
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis3[1], 6[2]

Ratio Explanation:

The ratio likely reflects delta-5 desaturase (FADS1) activity, where lower FADS1 function leads to higher levels of the precursor dihomo-linolenate relative to other fatty acids.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS1 gene variants alter the balance of polyunsaturated fatty acids, which are precursors to inflammatory mediators.7[1], 8[2] This dysregulated lipid metabolism is linked to inflammatory skin and sinus conditions like dermatitis and sinusitis.9[3], 10[4], 11[5]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data