branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to palmitoleate (16:1n7)

Numerator Metabolite

Metabolite Accession: GCST90200249
Name: branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of palmitoleate (16:1n7)
Metabolite Accession: GCST90200388
Name: palmitoleate (16:1n7)
Hmdb Id: HMDB0003229
Super Pathway: NA
Sub Pathway: NA
Inchikey: SECPZKHBENQXJG

Associated Genomic Regions

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.134
Position:
102075479
SE (Ratio):
0.013
Effect Allele:
A
Z-score (Ratio):
10.103
Reference Allele:
G
-log10(P):
-53.587
MAF:
0.176
Beta (Num):
0.006
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
-0.128
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

Region: rs147794363

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.360
Position:
73271372
SE (Ratio):
0.047
Effect Allele:
T
Z-score (Ratio):
-7.615
Reference Allele:
C
-log10(P):
-31.264
MAF:
0.011
Beta (Num):
-0.246
Novel Locus:
Yes ✔️
SE (Num):
0.069
Beta (Den):
0.114
SE (Den):
0.068
No CNV overlap
rQTL cluster:
45
Reaction Distance:
NA
Closest Genes:
DPF3 DCAF4 ZFYVE1 RGS6 RBM25

Region: rs151154986

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.505
Position:
74040136
SE (Ratio):
0.030
Effect Allele:
A
Z-score (Ratio):
-16.989
Reference Allele:
G
-log10(P):
-147.375
MAF:
0.029
Beta (Num):
-0.480
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
0.025
SE (Den):
0.042
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism

Denominator Metabolite Explanation:

Fatty acid biosynthesis/desaturation

Ratio Explanation:

The ratio may reflect the balance of ACOT2's activity on C12:1-CoA versus the biosynthesis of palmitoleate (16:1n7), influencing fatty acid profiles.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The ACOT2 variant likely alters fatty acid metabolism, creating a lipid imbalance reflected by the ratio, which contributes to hypercholesterolemia and coronary atherosclerosis.4[1], 5[2], 6[3]

Phenotype Driver:

Metabolite-centric[both]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data