3-hydroxydecanoylcarnitine to branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid*

Numerator Metabolite

Structure of 3-hydroxydecanoylcarnitine
Metabolite Accession: GCST90200246
Name: 3-hydroxydecanoylcarnitine
Hmdb Id: HMDB0061636
Super Pathway: NA
Sub Pathway: NA
Inchikey: VCRSQDIROUELAR

Denominator Metabolite

Metabolite Accession: GCST90200249
Name: branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs151154986

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
0.538
Position:
74040136
SE (Ratio):
0.036
Effect Allele:
A
Z-score (Ratio):
14.792
Reference Allele:
G
-log10(P):
-112.320
MAF:
0.030
Beta (Num):
0.058
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
-0.480
SE (Den):
0.044
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation, acylcarnitine transport.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, fatty acid biosynthesis.8[1], 9[2], 10[3]

Ratio Explanation:

The ratio reflects the balance between a fatty acid oxidation intermediate (3-hydroxydecanoylcarnitine) and a free fatty acid, potentially influenced by ACOT2's regulation of acyl-CoA pools.3[1], 8[2], 5[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data