branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to eicosenoate (20:1)

Numerator Metabolite

Metabolite Accession: GCST90200249

Name: branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid*

Hmdb Id: NA

Super Pathway: NA

Sub Pathway: NA

Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90199744

Name: eicosenoate (20:1)

Hmdb Id: HMDB0002231,HMDB0062436

Super Pathway: NA

Sub Pathway: NA

Inchikey: BITHHVVYSMSWAG

Associated Genomic Regions

Region: rs151154986

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:

Beta (Ratio):

-0.512

Position:

74040136

SE (Ratio):

0.033

Effect Allele:

Z-score (Ratio):

-15.471

Reference Allele:

-log10(P):

-122.643

MAF:

0.029

Beta (Num):

-0.480

Novel Locus:

SE (Num):

0.044

Beta (Den):

0.032

SE (Den):

0.045

No CNV overlap

rQTL cluster:

Reaction Distance:

Closest Genes:

ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis3^[1]

Denominator Metabolite Explanation:

Fatty acid elongation4^[1]

Ratio Explanation:

The ratio may reflect the balance between de novo synthesis/hydrolysis of medium/long-chain fatty acids (catalyzed by ACOT enzymes) and elongation to very-long-chain fatty acids.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data