branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to (16 or 17)-methylstearate (a19:0 or i19:0)

Numerator Metabolite

Metabolite Accession: GCST90200249
Name: branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of (16 or 17)-methylstearate (a19:0 or i19:0)
Metabolite Accession: GCST90199887
Name: (16 or 17)-methylstearate (a19:0 or i19:0)
Hmdb Id: HMDB0037397
Super Pathway: NA
Sub Pathway: NA
Inchikey: YETXGSGCWODRAA

Associated Genomic Regions

Region: rs151154986

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.487
Position:
74040136
SE (Ratio):
0.036
Effect Allele:
A
Z-score (Ratio):
-13.451
Reference Allele:
G
-log10(P):
-93.302
MAF:
0.029
Beta (Num):
-0.480
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
0.007
SE (Den):
0.044
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Numerator Pathway(s): Fatty acid biosynthesis and metabolism.6[1], 7[2]

Denominator Metabolite Explanation:

Denominator Pathway(s): Branched-chain fatty acid metabolism.8[1], 9[2], 10[3]

Ratio Explanation:

Ratio Interpretation: The ratio likely reflects the relative activity of ACOT enzymes on different fatty acyl-CoA substrates, influencing the balance between straight-chain/monounsaturated and branched-chain fatty acids.1[1], 11[2]

Ratio Evidence:

Ratio Evidence Level: metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Ratio-Phenotype Link: No phenotype association was provided in the input data, so a direct link between the ACOT-driven metabolic ratio and a specific phenotype cannot be established.

Phenotype Driver:

Primary Driver Of Phenotype Link: none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data