branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to docosapentaenoate (n6 dpa; 22:5n6)

Numerator Metabolite

Metabolite Accession: GCST90200249
Name: branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of docosapentaenoate (n6 dpa; 22:5n6)
Metabolite Accession: GCST90199796
Name: docosapentaenoate (n6 dpa; 22:5n6)
Hmdb Id: HMDB0001976
Super Pathway: NA
Sub Pathway: NA
Inchikey: AVKOENOBFIYBSA

Associated Genomic Regions

Region: rs174570

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.183
Position:
61597212
SE (Ratio):
0.019
Effect Allele:
T
Z-score (Ratio):
9.695
Reference Allele:
C
-log10(P):
-49.502
MAF:
0.131
Beta (Num):
0.020
Novel Locus:
No
SE (Num):
0.022
Beta (Den):
-0.162
SE (Den):
0.023
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

Region: rs151154986

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.555
Position:
74040136
SE (Ratio):
0.038
Effect Allele:
A
Z-score (Ratio):
-14.665
Reference Allele:
G
-log10(P):
-110.446
MAF:
0.029
Beta (Num):
-0.480
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
0.075
SE (Den):
0.046
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis5[1], 6[2]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis7[1], 8[2], 9[3], 10[4], 11[5], 12[6], 13[7]

Ratio Explanation:

The ratio reflects the balance between medium-chain fatty acid breakdown, influenced by ACOT2, and the synthesis of long-chain polyunsaturated fatty acids.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered ACOT2 activity likely modifies fatty acid pools, influencing lipid-dependent signaling pathways implicated in type 2 diabetes and skin cancer development.14[1], 15[2], 16[3], 17[4], 18[5], 19[6], 20[7], 21[8], 22[9]

Phenotype Driver:

Gene-centric:ACOT2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data