tetradecadienoate (14:2)* to dodecadienoate (12:2)*

Numerator Metabolite

Structure of tetradecadienoate (14:2)*
Metabolite Accession: GCST90200187
Name: tetradecadienoate (14:2)*
Hmdb Id: HMDB0000560
Super Pathway: NA
Sub Pathway: NA
Inchikey: HXHZGHRLVRFQDR

Denominator Metabolite

Metabolite Accession: GCST90200190
Name: dodecadienoate (12:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs148925835

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
0.308
Position:
73282698
SE (Ratio):
0.040
Effect Allele:
G
Z-score (Ratio):
7.721
Reference Allele:
T
-log10(P):
-32.091
MAF:
0.010
Beta (Num):
-0.071
Novel Locus:
Yes ✔️
SE (Num):
0.072
Beta (Den):
-0.379
SE (Den):
0.073
No CNV overlap
rQTL cluster:
45
Reaction Distance:
NA
Closest Genes:
DPF3 DCAF4 ZFYVE1 RBM25 RGS6

Region: rs151154986

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
0.439
Position:
74040136
SE (Ratio):
0.024
Effect Allele:
A
Z-score (Ratio):
18.426
Reference Allele:
G
-log10(P):
-172.894
MAF:
0.030
Beta (Num):
-0.166
Novel Locus:
No
SE (Num):
0.043
Beta (Den):
-0.605
SE (Den):
0.044
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

Region: rs11541763;rs141600125

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Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
-0.135
Position:
2301520
SE (Ratio):
0.011
Effect Allele:
C
Z-score (Ratio):
-12.059
Reference Allele:
G
-log10(P):
-75.433
MAF:
0.158
Beta (Num):
0.023
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.158
SE (Den):
0.021
No CNV overlap
rQTL cluster:
35
Reaction Distance:
NA
Closest Genes:
ECI1 RNPS1 AC009065.1 DNASE1L2 E4F1

Region: rs7757606

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Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.075
Position:
4119704
SE (Ratio):
0.009
Effect Allele:
A
Z-score (Ratio):
-8.556
Reference Allele:
G
-log10(P):
-38.987
MAF:
0.315
Beta (Num):
0.012
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.087
SE (Den):
0.016
No CNV overlap
rQTL cluster:
113
Reaction Distance:
NA
Closest Genes:
ECI2 C6orf201 FAM217A PRPF4B C6ORF50

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Fatty acid beta-oxidation

Ratio Explanation:

This ratio may reflect the relative activity of enzymes in fatty acid beta-oxidation, where tetradecadienoate (14:2) and dodecadienoate (12:2) are intermediates.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

A variant in ACOT2 and differential expression or function of ECI1 and ECI2 could alter the efficiency of fatty acid beta-oxidation, thereby affecting the relative levels of tetradecadienoate (14:2) and dodecadienoate (12:2), though a direct phenotypic consequence is not specified.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data