branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to docosapentaenoate n3 DPA; 22:5n3

Numerator Metabolite

Metabolite Accession: GCST90200249
Name: branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Associated Genomic Regions

Region: rs174574

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.142
Position:
61600342
SE (Ratio):
0.011
Effect Allele:
A
Z-score (Ratio):
12.800
Reference Allele:
C
-log10(P):
-84.697
MAF:
0.350
Beta (Num):
0.003
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.139
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 FADS3

Region: rs151154986

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.512
Position:
74040136
SE (Ratio):
0.031
Effect Allele:
A
Z-score (Ratio):
-16.463
Reference Allele:
G
-log10(P):
-138.548
MAF:
0.029
Beta (Num):
-0.480
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
0.032
SE (Den):
0.043
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis4[1], 5[2], 6[3]

Ratio Explanation:

The ratio reflects the balance between a shorter-chain fatty acid and a long-chain polyunsaturated fatty acid, DPA, whose synthesis is regulated by FADS enzymes.7[1], 5[2], 8[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters desaturase activity, affecting the balance of fatty acids like DPA and influencing lipid metabolism and related phenotypes like cholelithiasis and hypercholesterolemia.3[1], 9[2]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data