(2 or 3)-decenoate (10:1n7 or n8) to 10-heptadecenoate (17:1n7)

Numerator Metabolite

Metabolite Accession: GCST90200263
Name: (2 or 3)-decenoate (10:1n7 or n8)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 10-heptadecenoate (17:1n7)
Metabolite Accession: GCST90199731
Name: 10-heptadecenoate (17:1n7)
Hmdb Id: HMDB0060038
Super Pathway: NA
Sub Pathway: NA
Inchikey: GDTXICBNEOEPAZ

Associated Genomic Regions

Region: rs151154986

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.370
Position:
74040136
SE (Ratio):
0.037
Effect Allele:
A
Z-score (Ratio):
-10.073
Reference Allele:
G
-log10(P):
-53.281
MAF:
0.029
Beta (Num):
-0.345
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
0.025
SE (Den):
0.043
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid metabolism.3[1], 5[2]

Ratio Explanation:

ACOT2 hydrolyzes acyl-CoAs, including decenoyl-CoA.2[1] An altered ratio may reflect changes in ACOT2 activity impacting the relative pools of these fatty acids.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No associated phenotype was provided, so a link between the ACOT2 gene, the metabolite ratio, and a phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data