(2 or 3)-decenoate (10:1n7 or n8) to linolenate [alpha or gamma; (18:3n3 or 6)]

Numerator Metabolite

Metabolite Accession: GCST90200263
Name: (2 or 3)-decenoate (10:1n7 or n8)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of linolenate [alpha or gamma; (18:3n3 or 6)]
Metabolite Accession: GCST90199748
Name: linolenate [alpha or gamma; (18:3n3 or 6)]
Hmdb Id: HMDB0003073,HMDB0001388
Super Pathway: NA
Sub Pathway: NA
Inchikey: DTOSIQBPPRVQHS

Associated Genomic Regions

Region: rs151154986

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.395
Position:
74040136
SE (Ratio):
0.035
Effect Allele:
A
Z-score (Ratio):
-11.161
Reference Allele:
G
-log10(P):
-64.928
MAF:
0.029
Beta (Num):
-0.345
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
0.050
SE (Den):
0.043
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

Region: rs689308

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Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.161
Position:
4127730
SE (Ratio):
0.013
Effect Allele:
C
Z-score (Ratio):
12.446
Reference Allele:
A
-log10(P):
-80.205
MAF:
0.316
Beta (Num):
0.158
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.003
SE (Den):
0.016
No CNV overlap
rQTL cluster:
113
Reaction Distance:
NA
Closest Genes:
ECI2 C6orf201 FAM217A PRPF4B C6ORF50

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid β-oxidation.

Denominator Metabolite Explanation:

1[1], 2[2], 5[3] Fatty acid biosynthesis/metabolism.

Ratio Explanation:

6[1], 7[2], 8[3], 9[4] The ratio reflects the balance between fatty acid degradation (decenoate) and polyunsaturated fatty acid metabolism (linolenate), potentially influenced by ECI2's role in β-oxidation.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data