myristoleoylcarnitine (c14:1)* to dodecadienoate (12:2)*

Numerator Metabolite

Structure of myristoleoylcarnitine (c14:1)*
Metabolite Accession: GCST90199979
Name: myristoleoylcarnitine (c14:1)*
Hmdb Id: HMDB0240588
Super Pathway: NA
Sub Pathway: NA
Inchikey: ABVVZYXTZLEOHP

Denominator Metabolite

Metabolite Accession: GCST90200190
Name: dodecadienoate (12:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs2999545

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.155
Position:
151904146
SE (Ratio):
0.013
Effect Allele:
A
Z-score (Ratio):
11.768
Reference Allele:
T
-log10(P):
-71.944
MAF:
0.389
Beta (Num):
0.039
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.116
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D RORC

Region: rs151154986

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
0.626
Position:
74040136
SE (Ratio):
0.038
Effect Allele:
A
Z-score (Ratio):
16.565
Reference Allele:
G
-log10(P):
-140.229
MAF:
0.030
Beta (Num):
0.022
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
-0.605
SE (Den):
0.044
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

Region: rs441969

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Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
0.109
Position:
131702120
SE (Ratio):
0.013
Effect Allele:
G
Z-score (Ratio):
8.138
Reference Allele:
A
-log10(P):
-35.449
MAF:
0.377
Beta (Num):
0.068
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
-0.040
SE (Den):
0.015
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 SLC22A4 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, beta-oxidation.3[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Fatty acid metabolism, beta-oxidation.6[1], 7[2]

Ratio Explanation:

A higher ratio may indicate increased ACOT2 activity, which hydrolyzes myristoleoyl-CoA (a precursor to myristoleoylcarnitine), and potentially alters dicarboxylate levels through shifts in fatty acid oxidation.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

ACOT2 influences levels of long-chain acyl-CoAs, including the precursor to myristoleoylcarnitine.2[1], 8[2] Altered ACOT2 expression is linked to changes in blood cell counts and has been observed in acute myeloid leukemia, which aligns with the associated phenotypes of altered monocyte, platelet, and white blood cell counts.9[3], 10[4], 11[5]

Phenotype Driver:

Gene-centric:ACOT2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data