branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to myristoleate (14:1n5)

Numerator Metabolite

Metabolite Accession: GCST90200249
Name: branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of myristoleate (14:1n5)
Metabolite Accession: GCST90199715
Name: myristoleate (14:1n5)
Hmdb Id: HMDB0002000
Super Pathway: NA
Sub Pathway: NA
Inchikey: YWWVWXASSLXJHU

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
10
Beta (Ratio):
0.103
Position:
102075479
SE (Ratio):
0.013
Effect Allele:
A
Z-score (Ratio):
8.103
Reference Allele:
G
-log10(P):
-35.166
MAF:
0.176
Beta (Num):
0.006
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
-0.097
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

Region: rs151154986

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
14
Beta (Ratio):
-0.474
Position:
74040136
SE (Ratio):
0.028
Effect Allele:
A
Z-score (Ratio):
-16.668
Reference Allele:
G
-log10(P):
-141.954
MAF:
0.029
Beta (Num):
-0.480
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
-0.006
SE (Den):
0.042
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis/metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis/metabolism.7[1], 8[2]

Ratio Explanation:

The ratio reflects the balance of fatty acid metabolism, potentially influenced by ACOT1/2 which can act on C12-C20 acyl-CoAs.9[1], 10[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Altered ACOT1/2 function may shift fatty acid metabolism, influencing the availability of specific fatty acids linked to cardiovascular diseases and cholelithiasis.11[1], 12[2], 13[3], 14[4], 15[5]

Phenotype Driver:

Gene-centric:ACOT1/ACOT2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data