dodecadienoate (12:2)* to margarate (17:0)

Numerator Metabolite

Metabolite Accession: GCST90200190
Name: dodecadienoate (12:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of margarate (17:0)
Metabolite Accession: GCST90200459
Name: margarate (17:0)
Hmdb Id: HMDB0002259
Super Pathway: NA
Sub Pathway: NA
Inchikey: KEMQGTRYUADPNZ

Associated Genomic Regions

Region: rs113860908

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.519
Position:
74070803
SE (Ratio):
0.034
Effect Allele:
G
Z-score (Ratio):
-15.305
Reference Allele:
A
-log10(P):
-120.085
MAF:
0.042
Beta (Num):
-0.465
Novel Locus:
No
SE (Num):
0.037
Beta (Den):
0.054
SE (Den):
0.038
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT6 ACOT4 ACOT2 DNAL1 HEATR4

LLM Analysis

Numerator Metabolite Explanation:

Fatty Acid Dicarboxylate Metabolism3[1], 4[2]

Denominator Metabolite Explanation:

Long-chain saturated fatty acid metabolism5[1], 6[2]

Ratio Explanation:

The ratio may reflect the activity of THEM4, which can hydrolyze acyl-CoAs of both fatty acids, thus influencing their relative abundance.1[1], 7[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data