dodecadienoate (12:2)* to stearidonate (18:4n3)

Numerator Metabolite

Metabolite Accession: GCST90200190
Name: dodecadienoate (12:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of stearidonate (18:4n3)
Metabolite Accession: GCST90199721
Name: stearidonate (18:4n3)
Hmdb Id: HMDB0006547
Super Pathway: NA
Sub Pathway: NA
Inchikey: JIWBIWFOSCKQMA

Associated Genomic Regions

Region: rs2727270

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.206
Position:
61603237
SE (Ratio):
0.021
Effect Allele:
T
Z-score (Ratio):
9.982
Reference Allele:
C
-log10(P):
-52.352
MAF:
0.116
Beta (Num):
0.047
Novel Locus:
No
SE (Num):
0.023
Beta (Den):
-0.159
SE (Den):
0.022
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FADS3 FEN1 TMEM258

Region: rs151154986

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.681
Position:
74040136
SE (Ratio):
0.039
Effect Allele:
A
Z-score (Ratio):
-17.365
Reference Allele:
G
-log10(P):
-153.856
MAF:
0.030
Beta (Num):
-0.605
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
0.076
SE (Den):
0.043
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism

Denominator Metabolite Explanation:

Alpha-linolenic acid metabolism6[1], 7[2], 8[3]

Ratio Explanation:

The ratio of dodecadienoate to stearidonate may reflect a shift in fatty acid metabolism, influenced by FADS2 activity on PUFA synthesis.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in the FADS cluster (FADS1/FADS2) alters polyunsaturated fatty acid metabolism, which is linked to inflammation and cell signaling, thereby influencing risk for type 2 diabetes and various cancers, including colon, skin, and lung.9[1], 10[2], 11[3], 12[4], 13[5], 14[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data