3-hydroxydecanoylcarnitine to (2 or 3)-decenoate (10:1n7 or n8)

Numerator Metabolite

Metabolite Accession: GCST90200246

Name: 3-hydroxydecanoylcarnitine

Hmdb Id: HMDB0061636

Super Pathway: NA

Sub Pathway: NA

Inchikey: VCRSQDIROUELAR

Denominator Metabolite

Metabolite Accession: GCST90200263

Name: (2 or 3)-decenoate (10:1n7 or n8)

Hmdb Id: NA

Super Pathway: NA

Sub Pathway: NA

Inchikey: NA

Associated Genomic Regions

Region: rs151154986

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:

Beta (Ratio):

0.403

Position:

74040136

SE (Ratio):

0.039

Effect Allele:

Z-score (Ratio):

10.245

Reference Allele:

-log10(P):

-55.041

MAF:

0.030

Beta (Num):

0.058

Novel Locus:

SE (Num):

0.044

Beta (Den):

-0.345

SE (Den):

0.044

No CNV overlap

rQTL cluster:

Reaction Distance:

Closest Genes:

ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Fatty acid metabolism

Ratio Explanation:

An elevated 3-hydroxydecanoylcarnitine to decenoate ratio may suggest modulated ACOT2 activity impacting the balance of intermediates within the mitochondrial fatty acid oxidation pathway.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

A missense variant in ACOT2, a gene integral to mitochondrial fatty acid metabolism, could alter enzyme function, leading to an imbalance between 3-hydroxydecanoylcarnitine and decenoate. This ratio reflects a shift in fatty acid beta-oxidation, though no associated phenotype is provided to establish a full causal link.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data