adrenate (22:4n6) to dodecadienoate (12:2)*

Numerator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Denominator Metabolite

Metabolite Accession: GCST90200190
Name: dodecadienoate (12:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs28415528

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.146
Position:
151879761
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
9.684
Reference Allele:
G
-log10(P):
-49.397
MAF:
0.318
Beta (Num):
0.031
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.115
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

Region: rs151154986

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
0.656
Position:
74040136
SE (Ratio):
0.041
Effect Allele:
A
Z-score (Ratio):
15.947
Reference Allele:
G
-log10(P):
-130.147
MAF:
0.030
Beta (Num):
0.051
Novel Locus:
No
SE (Num):
0.045
Beta (Den):
-0.605
SE (Den):
0.044
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Omega-6 fatty acid biosynthesis.3[1]

Denominator Metabolite Explanation:

Fatty acid metabolism/beta-oxidation.4[1]

Ratio Explanation:

The ratio of adrenate (a long-chain PUFA) to dodecadienoate (a medium-chain fatty acid) reflects the activity of FADS-mediated fatty acid elongation and desaturation.5[1], 6[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered FADS1/FADS2 activity, indicated by the adrenate to dodecadienoate ratio, impacts fatty acid profiles, which is a known risk factor for cholelithiasis and dyslipidemia.7[1], 8[2], 9[3] This dysregulation of lipid metabolism can influence bile composition and systemic lipid levels, contributing to the observed phenotypes.10[4], 11[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data