branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to myristate (14:0)

Numerator Metabolite

Metabolite Accession: GCST90200249
Name: branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of myristate (14:0)
Metabolite Accession: GCST90200414
Name: myristate (14:0)
Hmdb Id: HMDB0000806
Super Pathway: NA
Sub Pathway: NA
Inchikey: TUNFSRHWOTWDNC

Associated Genomic Regions

Region: rs147794363

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.393
Position:
73271372
SE (Ratio):
0.052
Effect Allele:
T
Z-score (Ratio):
-7.579
Reference Allele:
C
-log10(P):
-30.992
MAF:
0.011
Beta (Num):
-0.246
Novel Locus:
Yes ✔️
SE (Num):
0.069
Beta (Den):
0.147
SE (Den):
0.069
No CNV overlap
rQTL cluster:
45
Reaction Distance:
NA
Closest Genes:
DPF3 DCAF4 ZFYVE1 RGS6 RBM25

Region: rs151154986

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.500
Position:
74040136
SE (Ratio):
0.033
Effect Allele:
A
Z-score (Ratio):
-15.380
Reference Allele:
G
-log10(P):
-121.234
MAF:
0.029
Beta (Num):
-0.480
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
0.020
SE (Den):
0.043
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism/biosynthesis.3[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Fatty acid metabolism/biosynthesis.6[1], 7[2], 3[3], 5[4]

Ratio Explanation:

ACOT2 has high activity for myristoyl-CoA (14:0) and other long-chain acyl-CoAs, suggesting the ratio reflects ACOT2's role in modulating fatty acid pools.1[1], 8[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No associated phenotype was provided; therefore, a link between the gene, metabolite ratio, and a phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data