branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to 5-dodecenoate (12:1n7)

Numerator Metabolite

Metabolite Accession: GCST90200249
Name: branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 5-dodecenoate (12:1n7)
Metabolite Accession: GCST90199723
Name: 5-dodecenoate (12:1n7)
Hmdb Id: HMDB0000529
Super Pathway: NA
Sub Pathway: NA
Inchikey: IJBFSOLHRKELLR

Associated Genomic Regions

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.118
Position:
102075479
SE (Ratio):
0.011
Effect Allele:
A
Z-score (Ratio):
10.755
Reference Allele:
G
-log10(P):
-60.446
MAF:
0.176
Beta (Num):
0.006
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
-0.112
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

Region: rs151154986

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.348
Position:
74040136
SE (Ratio):
0.025
Effect Allele:
A
Z-score (Ratio):
-14.124
Reference Allele:
G
-log10(P):
-102.629
MAF:
0.029
Beta (Num):
-0.480
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
-0.132
SE (Den):
0.042
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis, Beta-oxidation

Denominator Metabolite Explanation:

Fatty acid biosynthesis, Beta-oxidation

Ratio Explanation:

A higher ratio may indicate increased ACOT2 activity, which hydrolyzes various C12:1-CoAs (numerator) to free fatty acids, potentially altering the pool available for desaturation to 5-dodecenoate.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Elevated ACOT2 activity, possibly influenced by genetic variants, could alter the balance of specific fatty acids, contributing to dyslipidemia and increased risk for cardiometabolic diseases like myocardial infarction and hypercholesterolemia.5[1], 6[2], 7[3], 8[4], 9[5]

Phenotype Driver:

Gene-centric:ACOT2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data