dodecadienoate (12:2)* to 10-nonadecenoate (19:1n9)

Numerator Metabolite

Metabolite Accession: GCST90200190
Name: dodecadienoate (12:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 10-nonadecenoate (19:1n9)
Metabolite Accession: GCST90199728
Name: 10-nonadecenoate (19:1n9)
Hmdb Id: HMDB0013622
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBOWBNGUEWHNQZ

Associated Genomic Regions

Region: rs2999545

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.134
Position:
151904146
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
-9.704
Reference Allele:
T
-log10(P):
-49.596
MAF:
0.388
Beta (Num):
-0.116
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.018
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D RORC

Region: rs151154986

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.637
Position:
74040136
SE (Ratio):
0.040
Effect Allele:
A
Z-score (Ratio):
-16.076
Reference Allele:
G
-log10(P):
-132.231
MAF:
0.030
Beta (Num):
-0.605
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
0.032
SE (Den):
0.044
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, dicarboxylic acid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid metabolism, lipid metabolism.6[1], 7[2]

Ratio Explanation:

The ratio may reflect ACOT2's substrate preference, influencing the balance between mitochondrial medium-chain dicarboxylic fatty acids and long-chain monounsaturated fatty acids.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in ACOT2 likely alters its thioesterase activity, impacting the balance of mitochondrial medium- and long-chain fatty acids, but no specific phenotype link is provided in the input data.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data