branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to 10-nonadecenoate (19:1n9)

Numerator Metabolite

Metabolite Accession: GCST90200249
Name: branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 10-nonadecenoate (19:1n9)
Metabolite Accession: GCST90199728
Name: 10-nonadecenoate (19:1n9)
Hmdb Id: HMDB0013622
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBOWBNGUEWHNQZ

Associated Genomic Regions

Region: rs148925835

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.377
Position:
73282698
SE (Ratio):
0.049
Effect Allele:
G
Z-score (Ratio):
-7.637
Reference Allele:
T
-log10(P):
-31.441
MAF:
0.010
Beta (Num):
-0.290
Novel Locus:
Yes ✔️
SE (Num):
0.073
Beta (Den):
0.087
SE (Den):
0.073
No CNV overlap
rQTL cluster:
45
Reaction Distance:
NA
Closest Genes:
DPF3 DCAF4 ZFYVE1 RBM25 RGS6

Region: rs151154986

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.512
Position:
74040136
SE (Ratio):
0.030
Effect Allele:
A
Z-score (Ratio):
-17.252
Reference Allele:
G
-log10(P):
-151.892
MAF:
0.029
Beta (Num):
-0.480
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
0.032
SE (Den):
0.044
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, beta-oxidation.5[1]

Denominator Metabolite Explanation:

Fatty acid metabolism, beta-oxidation.6[1], 7[2]

Ratio Explanation:

The ratio likely reflects the relative mitochondrial hydrolysis of C12:1-CoA versus C19:1n9-CoA by ACOT2, which shows activity toward various long-chain acyl-CoAs.8[1], 4[2], 9[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

No phenotype data was provided; therefore, a causal link between the ACOT2-mediated ratio and a specific phenotype cannot be established from the input.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data