dihomo-linoleate (20:2n6) to dodecadienoate (12:2)*

Numerator Metabolite

Structure of dihomo-linoleate (20:2n6)
Metabolite Accession: GCST90200320
Name: dihomo-linoleate (20:2n6)
Hmdb Id: HMDB0005060
Super Pathway: NA
Sub Pathway: NA
Inchikey: XSXIVVZCUAHUJO

Denominator Metabolite

Metabolite Accession: GCST90200190
Name: dodecadienoate (12:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs28415528

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.137
Position:
151879761
SE (Ratio):
0.013
Effect Allele:
A
Z-score (Ratio):
10.652
Reference Allele:
G
-log10(P):
-59.332
MAF:
0.318
Beta (Num):
0.022
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.115
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

Region: rs151154986

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
0.645
Position:
74040136
SE (Ratio):
0.035
Effect Allele:
A
Z-score (Ratio):
18.464
Reference Allele:
G
-log10(P):
-173.612
MAF:
0.030
Beta (Num):
0.041
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
-0.605
SE (Den):
0.044
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis2[1], Linoleic acid metabolism3[2]

Denominator Metabolite Explanation:

Fatty acid metabolism4[1], 5[2]

Ratio Explanation:

The ratio likely reflects ACOT2 activity, which hydrolyzes both long-chain (dihomo-linoleate precursor) and medium-chain (dodecadienoate precursor) acyl-CoAs, influencing their relative abundance.6[1], 7[2], 8[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No associated phenotype is provided in the input data, so a direct causal link between the ACOT2 gene, the metabolite ratio, and a phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data