(2 or 3)-decenoate (10:1n7 or n8) to stearate (18:0)

Numerator Metabolite

Metabolite Accession: GCST90200263
Name: (2 or 3)-decenoate (10:1n7 or n8)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of stearate (18:0)
Metabolite Accession: GCST90200390
Name: stearate (18:0)
Hmdb Id: HMDB0000827
Super Pathway: NA
Sub Pathway: NA
Inchikey: QIQXTHQIDYTFRH

Associated Genomic Regions

Region: rs113860908

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.325
Position:
74070803
SE (Ratio):
0.032
Effect Allele:
G
Z-score (Ratio):
-10.070
Reference Allele:
A
-log10(P):
-53.249
MAF:
0.041
Beta (Num):
-0.255
Novel Locus:
No
SE (Num):
0.038
Beta (Den):
0.070
SE (Den):
0.038
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT6 ACOT4 ACOT2 DNAL1 HEATR4

Region: rs676683

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.156
Position:
4127253
SE (Ratio):
0.014
Effect Allele:
T
Z-score (Ratio):
11.295
Reference Allele:
C
-log10(P):
-66.443
MAF:
0.316
Beta (Num):
0.158
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.002
SE (Den):
0.016
No CNV overlap
rQTL cluster:
113
Reaction Distance:
NA
Closest Genes:
ECI2 C6orf201 FAM217A PRPF4B C6ORF50

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Fatty acid biosynthesis and elongation.4[1]

Ratio Explanation:

A lower ECI2 activity could impair beta-oxidation of decenoate (numerator), while stearate (denominator) metabolism is less affected, potentially altering their ratio.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data