dodecadienoate (12:2)* to stearate (18:0)

Numerator Metabolite

Metabolite Accession: GCST90200190
Name: dodecadienoate (12:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of stearate (18:0)
Metabolite Accession: GCST90200390
Name: stearate (18:0)
Hmdb Id: HMDB0000827
Super Pathway: NA
Sub Pathway: NA
Inchikey: QIQXTHQIDYTFRH

Associated Genomic Regions

Region: rs113860908

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.536
Position:
74070803
SE (Ratio):
0.034
Effect Allele:
G
Z-score (Ratio):
-15.653
Reference Allele:
A
-log10(P):
-125.489
MAF:
0.042
Beta (Num):
-0.465
Novel Locus:
No
SE (Num):
0.037
Beta (Den):
0.070
SE (Den):
0.038
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT6 ACOT4 ACOT2 DNAL1 HEATR4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation, fatty acid biosynthesis.

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, fatty acid biosynthesis.4[1]

Ratio Explanation:

The ratio reflects the balance between medium-chain (dodecadienoate) and long-chain (stearate) fatty acids, likely regulated by ACOT/THEM thioesterase activity on acyl-CoAs.5[1], 3[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No phenotype was associated with this ratio, so a causal link between the genetic factors, metabolic ratio, and a phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data