3-hydroxybutyrate to dodecadienoate (12:2)*

Numerator Metabolite

Structure of 3-hydroxybutyrate (bhba)
Metabolite Accession: GCST90200367
Name: 3-hydroxybutyrate (bhba)
Hmdb Id: HMDB0000011
Super Pathway: NA
Sub Pathway: NA
Inchikey: WHBMMWSBFZVSSR

Denominator Metabolite

Metabolite Accession: GCST90200190
Name: dodecadienoate (12:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs7523082

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.134
Position:
151848126
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
9.672
Reference Allele:
T
-log10(P):
-49.275
MAF:
0.396
Beta (Num):
0.016
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.119
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC LINGO4

Region: rs113860908

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
0.541
Position:
74070803
SE (Ratio):
0.034
Effect Allele:
G
Z-score (Ratio):
15.948
Reference Allele:
A
-log10(P):
-130.172
MAF:
0.042
Beta (Num):
0.076
Novel Locus:
No
SE (Num):
0.038
Beta (Den):
-0.465
SE (Den):
0.037
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT6 ACOT4 ACOT2 DNAL1 HEATR4

LLM Analysis

Numerator Metabolite Explanation:

Ketogenesis.4[1], 5[2], 6[3], 7[4]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.4[1], 8[2]

Ratio Explanation:

This ratio may reflect the balance between ketogenesis (numerator) and medium-chain fatty acid beta-oxidation (denominator), potentially modulated by ACOT2/THEM4 activity.1[1], 9[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

No associated phenotype was provided; therefore, a causal link between genetic factors, the metabolite ratio, and a phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data