branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to arachidonate (20:4n6)

Numerator Metabolite

Metabolite Accession: GCST90200249
Name: branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Associated Genomic Regions

Region: rs174567

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.315
Position:
61593005
SE (Ratio):
0.013
Effect Allele:
G
Z-score (Ratio):
23.795
Reference Allele:
A
-log10(P):
-286.503
MAF:
0.346
Beta (Num):
0.003
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.312
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

Region: rs151154986

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.516
Position:
74040136
SE (Ratio):
0.037
Effect Allele:
A
Z-score (Ratio):
-13.779
Reference Allele:
G
-log10(P):
-97.790
MAF:
0.029
Beta (Num):
-0.480
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
0.036
SE (Den):
0.044
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, Thioesterase pathway.5[1], 6[2]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis, Desaturase pathway.2[1], 7[2], 8[3]

Ratio Explanation:

This ratio reflects the balance between medium-chain fatty acid hydrolysis by ACOT enzymes and long-chain polyunsaturated fatty acid synthesis by FADS enzymes.5[1], 8[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in the FADS gene cluster alter fatty acid desaturation, affecting levels of arachidonate, a precursor for pro-inflammatory eicosanoids implicated in both cholelithiasis and colorectal neoplasms.9[1], 10[2], 11[3], 12[4]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data