(2 or 3)-decenoate (10:1n7 or n8) to Docosahexaenoate DHA; 22:6n3

Numerator Metabolite

Metabolite Accession: GCST90200263
Name: (2 or 3)-decenoate (10:1n7 or n8)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of docosahexaenoate (dha; 22:6n3)
Metabolite Accession: GCST90199651
Name: docosahexaenoate (dha; 22:6n3)
Hmdb Id: HMDB0002183
Super Pathway: NA
Sub Pathway: NA
Inchikey: MBMBGCFOFBJSGT

Associated Genomic Regions

Region: rs151154986

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.394
Position:
74040136
SE (Ratio):
0.041
Effect Allele:
A
Z-score (Ratio):
-9.626
Reference Allele:
G
-log10(P):
-48.830
MAF:
0.029
Beta (Num):
-0.345
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
0.049
SE (Den):
0.043
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

Region: rs689308

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Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.170
Position:
4127730
SE (Ratio):
0.015
Effect Allele:
C
Z-score (Ratio):
11.322
Reference Allele:
A
-log10(P):
-66.755
MAF:
0.316
Beta (Num):
0.158
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.012
SE (Den):
0.016
No CNV overlap
rQTL cluster:
113
Reaction Distance:
NA
Closest Genes:
ECI2 C6orf201 FAM217A PRPF4B C6ORF50

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Fatty acid synthesis and degradation.5[1], 6[2], 7[3]

Ratio Explanation:

An increased ratio may indicate altered ECI2 activity, impacting the balance between the breakdown of medium-chain and the synthesis of very-long-chain polyunsaturated fatty acids.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The ECI2 pQTL suggests a genetic influence on its protein levels, altering the ratio of (2 or 3)-decenoate to DHA. This could potentially modify fatty acid profiles, but no direct link to a phenotype is established with the provided information.

Phenotype Driver:

Gene-centric:ECI2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data