branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to 3-hydroxylaurate

Numerator Metabolite

Metabolite Accession: GCST90200249
Name: branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 3-hydroxylaurate
Metabolite Accession: GCST90199700
Name: 3-hydroxylaurate
Hmdb Id: HMDB0000387
Super Pathway: NA
Sub Pathway: NA
Inchikey: MUCMKTPAZLSKTL

Associated Genomic Regions

Region: rs28415528

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.102
Position:
151879761
SE (Ratio):
0.009
Effect Allele:
A
Z-score (Ratio):
11.567
Reference Allele:
G
-log10(P):
-69.580
MAF:
0.318
Beta (Num):
-0.004
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.105
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

Region: rs35259237

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.282
Position:
73890837
SE (Ratio):
0.035
Effect Allele:
A
Z-score (Ratio):
-8.007
Reference Allele:
C
-log10(P):
-34.378
MAF:
0.013
Beta (Num):
-0.298
Novel Locus:
No
SE (Num):
0.064
Beta (Den):
-0.016
SE (Den):
0.065
No CNV overlap
rQTL cluster:
45
Reaction Distance:
NA
Closest Genes:
NUMB HEATR4 ACOT1 ACOT2 PAPLN

Region: rs151154986

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.466
Position:
74040136
SE (Ratio):
0.024
Effect Allele:
A
Z-score (Ratio):
-19.474
Reference Allele:
G
-log10(P):
-192.824
MAF:
0.029
Beta (Num):
-0.480
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
-0.013
SE (Den):
0.044
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.6[1], 5[2]

Ratio Explanation:

This ratio reflects altered ACOT2-mediated hydrolysis of medium-chain acyl-CoAs, affecting the balance between dodecenoyl species and its beta-oxidation intermediate, 3-hydroxylaurate.3[1], 7[2], 8[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

No phenotype data is available. Genetic factors point to ACOT2-driven alterations in medium-chain fatty acid handling, but a link to a specific phenotype is not established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data