(2 or 3)-decenoate (10:1n7 or n8) to linoleate (18:2n6)

Numerator Metabolite

Metabolite Accession: GCST90200263
Name: (2 or 3)-decenoate (10:1n7 or n8)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of linoleate (18:2n6)
Metabolite Accession: GCST90200354
Name: linoleate (18:2n6)
Hmdb Id: HMDB0006270,HMDB0000673
Super Pathway: NA
Sub Pathway: NA
Inchikey: OYHQOLUKZRVURQ

Associated Genomic Regions

Region: rs148925835

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.457
Position:
73282698
SE (Ratio):
0.055
Effect Allele:
G
Z-score (Ratio):
-8.243
Reference Allele:
T
-log10(P):
-36.322
MAF:
0.010
Beta (Num):
-0.355
Novel Locus:
Yes ✔️
SE (Num):
0.074
Beta (Den):
0.101
SE (Den):
0.073
No CNV overlap
rQTL cluster:
45
Reaction Distance:
NA
Closest Genes:
DPF3 DCAF4 ZFYVE1 RBM25 RGS6

Region: rs151154986

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.377
Position:
74040136
SE (Ratio):
0.033
Effect Allele:
A
Z-score (Ratio):
-11.375
Reference Allele:
G
-log10(P):
-67.365
MAF:
0.029
Beta (Num):
-0.345
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
0.032
SE (Den):
0.044
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

Region: rs689308

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Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.162
Position:
4127730
SE (Ratio):
0.012
Effect Allele:
C
Z-score (Ratio):
13.356
Reference Allele:
A
-log10(P):
-92.017
MAF:
0.316
Beta (Num):
0.158
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.004
SE (Den):
0.016
No CNV overlap
rQTL cluster:
113
Reaction Distance:
NA
Closest Genes:
ECI2 C6orf201 FAM217A PRPF4B C6ORF50

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation.3[1], 4[2]

Denominator Metabolite Explanation:

Linoleic acid metabolism.5[1], 6[2]

Ratio Explanation:

The ratio reflects mitochondrial/peroxisomal beta-oxidation activity (producing decenoate from fatty acid breakdown) relative to the essential fatty acid linoleate pool.7[1], 8[2], 9[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No phenotype was provided, so a causal link cannot be established. Genetic factors like ACOT2 and ECI2 regulate fatty acid oxidation, which influences this ratio, but the ultimate phenotypic effect is unknown based on the data.10[1], 11[2], 12[3]

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data