dodecadienoate (12:2)* to palmitate (16:0)

Numerator Metabolite

Metabolite Accession: GCST90200190
Name: dodecadienoate (12:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of palmitate (16:0)
Metabolite Accession: GCST90200397
Name: palmitate (16:0)
Hmdb Id: HMDB0000220
Super Pathway: NA
Sub Pathway: NA
Inchikey: IPCSVZSSVZVIGE

Associated Genomic Regions

Region: rs148925835

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.490
Position:
73282698
SE (Ratio):
0.064
Effect Allele:
G
Z-score (Ratio):
-7.664
Reference Allele:
T
-log10(P):
-31.645
MAF:
0.010
Beta (Num):
-0.379
Novel Locus:
Yes ✔️
SE (Num):
0.073
Beta (Den):
0.111
SE (Den):
0.074
No CNV overlap
rQTL cluster:
45
Reaction Distance:
NA
Closest Genes:
DPF3 DCAF4 ZFYVE1 RBM25 RGS6

Region: rs151154986

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.663
Position:
74040136
SE (Ratio):
0.038
Effect Allele:
A
Z-score (Ratio):
-17.317
Reference Allele:
G
-log10(P):
-153.017
MAF:
0.030
Beta (Num):
-0.605
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
0.058
SE (Den):
0.044
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, omega-oxidation.

Denominator Metabolite Explanation:

Fatty acid synthesis, beta-oxidation.4[1], 5[2], 6[3]

Ratio Explanation:

ACOT2 acts on palmitoyl-CoA (precursor of palmitate) and other long-chain acyl-CoAs, influencing the overall fatty acid pool and potentially the balance with dodecadienoate.7[1], 8[2], 9[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data