dodecadienoate (12:2)* to palmitoleate (16:1n7)

Numerator Metabolite

Metabolite Accession: GCST90200190
Name: dodecadienoate (12:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of palmitoleate (16:1n7)
Metabolite Accession: GCST90200388
Name: palmitoleate (16:1n7)
Hmdb Id: HMDB0003229
Super Pathway: NA
Sub Pathway: NA
Inchikey: SECPZKHBENQXJG

Associated Genomic Regions

Region: rs151154986

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
14
Beta (Ratio):
-0.630
Position:
74040136
SE (Ratio):
0.038
Effect Allele:
A
Z-score (Ratio):
-16.458
Reference Allele:
G
-log10(P):
-138.469
MAF:
0.030
Beta (Num):
-0.605
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
0.025
SE (Den):
0.042
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism/biosynthesis

Denominator Metabolite Explanation:

Fatty acid metabolism/biosynthesis5[1], 6[2], 7[3]

Ratio Explanation:

A higher ratio may indicate increased ACOT2/ACOT4 activity, leading to elevated dodecadienoate relative to palmitoleate, potentially impacting lipid signaling and metabolism.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

A missense variant in ACOT2, alongside eQTL colocalization for ACOT2 and ACOT4, suggests altered acyl-CoA metabolism. This could change the dodecadienoate to palmitoleate ratio, although a direct phenotypic consequence is not established from the provided data.

Phenotype Driver:

Gene-centric:ACOT2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data