dodecadienoate (12:2)* to decanoylcarnitine (c10)

Numerator Metabolite

Metabolite Accession: GCST90200190
Name: dodecadienoate (12:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of decanoylcarnitine (c10)
Metabolite Accession: GCST90199722
Name: decanoylcarnitine (c10)
Hmdb Id: HMDB0000651
Super Pathway: NA
Sub Pathway: NA
Inchikey: LZOSYCMHQXPBFU

Associated Genomic Regions

Region: rs151154986

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.647
Position:
74040136
SE (Ratio):
0.042
Effect Allele:
A
Z-score (Ratio):
-15.422
Reference Allele:
G
-log10(P):
-121.888
MAF:
0.030
Beta (Num):
-0.605
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
0.042
SE (Den):
0.044
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid dicarboxylate metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid metabolism, beta-oxidation.7[1], 8[2]

Ratio Explanation:

The ratio likely reflects altered fatty acid oxidation, where decreased ACADM function could lead to accumulation of upstream fatty acids like dodecadienoate and decreased formation of downstream products like decanoylcarnitine.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

A functional deficiency in the ACADM gene, which is crucial for the breakdown of medium-chain fatty acids, could disrupt the balance between dodecadienoate and decanoylcarnitine.1[1], 4[2], 9[3] This enzymatic block may lead to an accumulation of certain fatty acids while depleting others, however, no direct phenotype link is provided.

Phenotype Driver:

Gene-centric:ACADM

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data