dodecadienoate (12:2)* to Docosahexaenoate DHA; 22:6n3

Numerator Metabolite

Metabolite Accession: GCST90200190
Name: dodecadienoate (12:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of docosahexaenoate (dha; 22:6n3)
Metabolite Accession: GCST90199651
Name: docosahexaenoate (dha; 22:6n3)
Hmdb Id: HMDB0002183
Super Pathway: NA
Sub Pathway: NA
Inchikey: MBMBGCFOFBJSGT

Associated Genomic Regions

Region: rs151154986

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.654
Position:
74040136
SE (Ratio):
0.041
Effect Allele:
A
Z-score (Ratio):
-16.048
Reference Allele:
G
-log10(P):
-131.769
MAF:
0.030
Beta (Num):
-0.605
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
0.049
SE (Den):
0.043
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid dicarboxylate metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, PUFA biosynthesis.6[1], 7[2]

Ratio Explanation:

The ratio reflects the balance between dicarboxylic fatty acid formation and polyunsaturated fatty acid metabolism, potentially modulated by ACOT2's regulation of acyl-CoA pools.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No associated phenotype is provided, so a causal link cannot be established between ACOT2, the metabolite ratio, and a phenotype.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data